ArticlePloS one2017
Reduced resting state connectivity and gray matter volume correlate with cognitive impairment in minimal hepatic encephalopathy.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Transcriptomic signatures of gray matter volume alterations in hepatic encephalopathy.Brain imaging and behavior · 2025Pooled it
- Correlation of ammonia and blood laboratory parameters with hepatic encephalopathy: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Brain microstructural abnormalities in patients with Wilson's disease: A systematic review of diffusion tenor imaging studies.Brain imaging and behavior · 2022Pooled it
- Brain Gray Matter Alterations in Hepatic Encephalopathy: A Voxel-Based Meta-Analysis of Whole-Brain Studies.Frontiers in human neuroscience · 2022Pooled it
- Dynamic network reconfiguration in hepatitis B cirrhosis secondary to mild hepatic encephalopathy: a multilayer network analysis.Quantitative imaging in medicine and surgery · 2026Article
- Association between liver biomarkers and risk of cognitive impairment and dementia: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2025Review
- Cortical microstructural changes in minimal hepatic encephalopathy: a gray matter-based spatial statistics study.Quantitative imaging in medicine and surgery · 2025Article
- Structural and functional neural correlates of sensorimotor deficits in progression of hepatic encephalopathy.Magnetic resonance letters · 2025Article
- Ammonia and beyond - biomarkers of hepatic encephalopathy.Metabolic brain disease · 2025Review
- Assessment of microstructural abnormalities in gray and white matter of minimal hepatic encephalopathy patients using diffusion kurtosis imaging and their associations with neurocognitive dysfunction.Frontiers in human neuroscience · 2025Article
- Quantitative susceptibility mapping reveals brain iron accumulation in minimal hepatic encephalopathy: associations with neurocognitive changes.Metabolic brain disease · 2024Article
- Improved cognition after rifaximin treatment is associated with changes in intra- and inter-brain network functional connectivity.Journal of translational medicine · 2024Article
- Automatic Video-Oculography System for Detection of Minimal Hepatic Encephalopathy Using Machine Learning Tools.Sensors (Basel, Switzerland) · 2023Article
- Minimal hepatic encephalopathy is associated to alterations in eye movements.Scientific reports · 2022Article
- Aberrant stability of brain functional architecture in cirrhotic patients with minimal hepatic encephalopathy.Brain imaging and behavior · 2022Article
- An Increased Aspartate to Alanine Aminotransferase Ratio Is Associated With a Higher Risk of Cognitive Impairment.Frontiers in medicine · 2022Article
- Structural and functional brain changes in hepatic and neurological Wilson disease.Brain imaging and behavior · 2021Article
- Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function.Journal of clinical medicine · 2021Article
- Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy.Journal of clinical medicine · 2020Article
- Changes of Brain Structure in Patients With Metastatic Non-Small Cell Lung Cancer After Long-Term Target Therapy With EGFR-TKI.Frontiers in oncology · 2020Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsMinimal hepatic encephalopathy (MHE) is associated with cognitive alterations and changes in connectivity. We assessed the relationship of the abnormalities of resting-state functional connectivity (rs-FC) and gray matter (GM) volume with different cognitive alterations and biochemical parameters associated to MHE.
methodsThirty-nine cirrhotic patients (26 without and 13 with MHE) and 24 controls were widely cognitive assessed with a battery of psychometric tests. Atrophy was determined using Voxel-Based Morphometry and rs-FC was assessed by independent component analysis. Receiver operating characteristic (ROC) curves was performed to assess the diagnostic utility of rs-FC and GM reduction for the discrimination of patients with and without MHE. Blood ammonia, cGMP, and levels of pro-inflammatory interleukins were measured.
resultsMHE patients showed significant decrease of GM volume and lesser degree of rs-FC in different networks related to attention and executive functions as compared to controls and patients without MHE. There is a progressive reduction in rs-FC in the default mode network with the progression of cognitive impairment. MHE patients showed GM reduction in the right frontal lobe, right insula and right cerebellum compared to patients without MHE. Alterations in GM volume and rs-FC correlated with the scores of different cognitive tests.
conclusionsDecreased cognitive performance is associated by reduced rs-FC and GM atrophy in MHE patients. These changes could have predictive value for detecting MHE.
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