ArticlePloS one2017
A multilayered electrospun graft as vascular access for hemodialysis.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Redefining vascular repair: revealing cellular responses on PEUU-gelatin electrospun vascular grafts for endothelialization and immune responses onFrontiers in bioengineering and biotechnology · 2024Article
- Manufacturing the multiscale vascular hierarchy: progress toward solving the grand challenge of tissue engineering.Trends in biotechnology · 2023Review
- Optimization of FDM 3D printing process parameters to produce haemodialysis curcumin-loaded vascular grafts.Drug delivery and translational research · 2023Article
- Visualization of porosity and pore size gradients in electrospun scaffolds using laser metrology.PloS one · 2023Article
- Review
- Decellularization of Full Heart-Optimizing the Classical Sodium-Dodecyl-Sulfate-Based Decellularization Protocol.Bioengineering (Basel, Switzerland) · 2022Article
- Review
- Fabrication and Characterization of PCL/PLGA Coaxial and Bilayer Fibrous Scaffolds for Tissue Engineering.Materials (Basel, Switzerland) · 2021Article
- Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies.ACS biomaterials science & engineering · 2021Review
- Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft.Bioactive materials · 2021Review
- Article
- Improvement of the Electronic-Neuronal Interface by Natural Deposition of ECM.Materials (Basel, Switzerland) · 2021Article
- Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs).PloS one · 2020Article
- Vascular Tissue Engineering: Polymers and Methodologies for Small Caliber Vascular Grafts.Frontiers in cardiovascular medicine · 2020Review
- Influence of Electrical Field Collector Positioning and Motion Scheme on Electrospun Bifurcated Vascular Graft Membranes.Materials (Basel, Switzerland) · 2019Article
- The formulation and characterization of 3D printed grafts as vascular access for potential use in hemodialysis.RSC advances · 2018Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Despite medical achievements, the number of patients with end-stage kidney disease keeps steadily raising, thereby entailing a high number of surgical and interventional procedures to establish and maintain arteriovenous vascular access for hemodialysis. Due to vascular disease, aneurysms or infection, the preferred access-an autogenous arteriovenous fistula-is not always available and appropriate. Moreover, when replacing small diameter blood vessels, synthetic vascular grafts possess well-known disadvantages. A continuous multilayered gradient electrospinning was used to produce vascular grafts made of collagen type I nanofibers on luminal and adventitial graft side, and poly-ɛ-caprolactone as medial layer. Therefore, a custom-made electrospinner with robust environmental control was developed. The morphology of electrospun grafts was characterized by scanning electron microscopy and measurement of mechanical properties. Human microvascular endothelial cells were cultured in the graft under static culture conditions and compared to cultures obtained from dynamic continuous flow bioreactors. Immunofluorescent analysis showed that endothelial cells form a continuous luminal layer and functional characteristics were confirmed by uptake of acetylated low-density-lipoprotein. Incorporation of vancomycin and gentamicin to the medial graft layer allowed antimicrobial inhibition without exhibiting an adverse impact on cell viability. Most striking a physiological hemocompatibility was achieved for the multilayered grafts.
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