ArticlePLoS biology2017
The sea cucumber genome provides insights into morphological evolution and visceral regeneration.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
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Who cites it
105 citing papers in PubMed, 275 citations in OpenAlex.
- The Sea Cucumber Holobiont and Probiotics: Recent Progress on Apostichopus japonicus.Current microbiology · 2026Review
- Natural tissue immortality: Indefinite survival of sea cucumber explants.Science advances · 2026Article
- Sea CucumberResearch square · 2026Article
- Evolutionary innovation within conserved gene regulatory networks underlying biomineralized skeletons in Bilateria.Molecular biology and evolution · 2026Article
- Therapeutic Potential of Sea Cucumber-Derived Bioactives in the Prevention and Management of Brain-Related Disorders: A Comprehensive Review.Marine drugs · 2025Review
- A chromosomal-level genome assembly of the tropical sea cucumber Stichopus fusiformiossa.Scientific data · 2025Article
- Screening and heterologous expression of an antimicrobial peptide SCAK33 with broad-spectrum antimicrobial activity resourced from sea cucumber proteome.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- The neuropeptidomes of the sea cucumbers Stichopus cf. horrens and Holothuria scabra.Scientific reports · 2025Article
- Deciphering Probiotic Effects of Sulfitobacter pontiacus Strain BL28 on the Host Sea Cucumber Apostichopus japonicus.Current microbiology · 2025Article
- Comprehensive analysis of Metacrinus rotundus full length transcriptome.Scientific reports · 2025Article
- Coding Genes Helped the Origination and Diversification of Intragenic MicroRNAs.Molecular biology and evolution · 2025Article
- Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinoderms.Cell communication and signaling : CCS · 2025Article
- LncRNA-miRNA interplay regulate intestinal regeneration in the sea cucumberComputational and structural biotechnology journal · 2025Article
- Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates.Science advances · 2024Article
- Identification of Key Genes Correlated with Economic Trait Superiorities and Their SNP Screening Through Transcriptome Comparisons, WGCNA and Pearson Correlation Coefficient in the Sea Cucumber Apostichopus Japonicus.Marine biotechnology (New York, N.Y.) · 2024Article
- Advances in biotechnology and breeding innovations in China's marine aquaculture.Advanced biotechnology · 2024Review
- Article
- Sea cucumbers and their symbiotic microbiome have evolved to feed on seabed sediments.Nature communications · 2024Article
- Shared regulatory function of non-genomic thyroid hormone signaling in echinoderm skeletogenesis.EvoDevo · 2024Article
- Brittle star genome provides information on the evolution of regeneration.Nature ecology & evolution · 2024Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
31 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apart from sharing common ancestry with chordates, sea cucumbers exhibit a unique morphology and exceptional regenerative capacity. Here we present the complete genome sequence of an economically important sea cucumber, A. japonicus, generated using Illumina and PacBio platforms, to achieve an assembly of approximately 805 Mb (contig N50 of 190 Kb and scaffold N50 of 486 Kb), with 30,350 protein-coding genes and high continuity. We used this resource to explore key genetic mechanisms behind the unique biological characters of sea cucumbers. Phylogenetic and comparative genomic analyses revealed the presence of marker genes associated with notochord and gill slits, suggesting that these chordate features were present in ancestral echinoderms. The unique shape and weak mineralization of the sea cucumber adult body were also preliminarily explained by the contraction of biomineralization genes. Genome, transcriptome, and proteome analyses of organ regrowth after induced evisceration provided insight into the molecular underpinnings of visceral regeneration, including a specific tandem-duplicated prostatic secretory protein of 94 amino acids (PSP94)-like gene family and a significantly expanded fibrinogen-related protein (FREP) gene family. This high-quality genome resource will provide a useful framework for future research into biological processes and evolution in deuterostomes, including remarkable regenerative abilities that could have medical applications. Moreover, the multiomics data will be of prime value for commercial sea cucumber breeding programs.
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