Evidence map›Paper›PMID 29023449›Full record

ArticlePLoS computational biology2017

Network propagation in the cytoscape cyberinfrastructure.

Daniel E Carlin, Barry Demchak, Dexter Pratt, Eric Sage, Trey Ideker

Abstract read
In one paragraph

Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Genetic overlap between treatment-resistant schizophrenia and smoking initiation.The international journal of neuropsychopharmacology · 2026
    Article
  3. Article
  4. Taxonomic and biosynthetic diversity of the marine actinomyceteApplied and environmental microbiology · 2026
    Article
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  7. Review
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  19. Integrative Analysis of the Ethanol Tolerance ofInternational journal of molecular sciences · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel E CarlinDepartment of Medicine, University of California-San Diego, San Diego, California, United States of America.ORCID http://orcid.org/0000-0001-5075-9486
Barry DemchakDepartment of Medicine, University of California-San Diego, San Diego, California, United States of America.
Dexter PrattDepartment of Medicine, University of California-San Diego, San Diego, California, United States of America.
Eric SageDepartment of Medicine, University of California-San Diego, San Diego, California, United States of America.
Trey IdekerDepartment of Medicine, University of California-San Diego, San Diego, California, United States of America.

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
NDEx - the Network Data Exchange A Network Commons for BiologistsU24CA184427 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PRATT, DEXTER · 2014 to 2021
$5.7M
NCI NIH HHS U24 CA184427NIGMS NIH HHS P41 GM103504
6 · The paper itself

Abstract

Network propagation is an important and widely used algorithm in systems biology, with applications in protein function prediction, disease gene prioritization, and patient stratification. However, up to this point it has required significant expertise to run. Here we extend the popular network analysis program Cytoscape to perform network propagation as an integrated function. Such integration greatly increases the access to network propagation by putting it in the hands of biologists and linking it to the many other types of network analysis and visualization available through Cytoscape. We demonstrate the power and utility of the algorithm by identifying mutations conferring resistance to Vemurafenib.

Indexed as

AlgorithmsSoftwareAnimalsDrug Resistance, NeoplasmIndolesModels, BiologicalMutationProtein Interaction MappingSulfonamidesSystems BiologyVemurafenibIndolesSulfonamidesVemurafenib

Identifiers

PMID29023449
PMCPMC5638226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.