ArticleNanomaterials (Basel, Switzerland)2017
Nanometric MIL-125-NH₂ Metal-Organic Framework as a Potential Nerve Agent Antidote Carrier.
Article in Nanomaterials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 91 citations in OpenAlex.
- Galvanic Replacement Incorporation of Ultrasmall Gold-Silver Nanoparticles within a Titanium Aminoterephthalate Framework.Chemistry of materials : a publication of the American Chemical Society · 2026Article
- From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Review
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- Catalytically Active Ti-Based Nanomaterials for Hydroxyl Radical Mediated Clinical X-Ray Enhancement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Insights into the Biological Activity and Bio-Interaction Properties of Nanoscale Imine-Based 2D and 3D Covalent Organic Frameworks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review
- Strategies for enhanced bioavailability of oxime reactivators in the central nervous system.Archives of toxicology · 2023Review
- Carboxymethyl cellulose/sulfur-functionalized Ti-based MOF composite: synthesis, characterization, antimicrobial, antiviral and anticancer potentiality.Discover nano · 2023Article
- Oxime@Zirconium-Metal-Organic Framework Hybrid Material as a Potential Antidote for Organophosphate Poisoning.Inorganic chemistry · 2023Article
- Antiadherent AgBDC Metal-Organic Framework Coating forPharmaceutics · 2023Article
- Cellular fate and performance of group IV metal organic framework radioenhancers.Biomaterials science · 2022Article
- Cation-Exchangeable Pralidoxime Chloride@bio-MOF-1 as a Treatment for Nerve Agent Poisoning and Sulfur Mustard Skin Poisoning in Animals.ACS omega · 2022Article
- Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents.Drug delivery · 2021Article
- Formulation of Metal-Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility.Journal of the American Chemical Society · 2021Article
- Nanomaterial-Enabled Sensors and Therapeutic Platforms for Reactive Organophosphates.Nanomaterials (Basel, Switzerland) · 2021Review
- Synergic effect of doxorubicin release and two-photon irradiation of MnRSC advances · 2020Article
- Size control over metal-organic framework porous nanocrystals.Chemical science · 2019Review
- Enhanced photocatalytic performance of a Ti-based metal-organic framework for hydrogen production: Hybridization with ZnCr-LDH nanosheets.Scientific reports · 2019Article
- Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy.Angewandte Chemie (International ed. in English) · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH₂ (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 °C/32 h under atmospheric pressure) so that for the first time it could be considered for encapsulation and the release of drugs. The nerve agent antidote 2-[(hydroxyimino)methyl]-1-methyl-pyridinium chloride (2-PAM or pralidoxime) was effectively encapsulated into the pores of MIL-125-NH₂ as a result of the interactions between 2-PAM and the pore walls being mediated by π-stacking and hydrogen bonds, as deduced from infrared spectroscopy and Monte Carlo simulation studies. Finally, colloidal solutions of MIL-125-NH₂ nanoparticles exhibited remarkable stability in different organic media, aqueous solutions at different pH and under relevant physiological conditions over time (24 h). 2-PAM was rapidly released from the pores of MIL-125-NH₂ in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.