Evidence map›Paper›PMID 29023421›Full record

ReviewToxins2017

Helicobacter pylori Vacuolating Toxin and Gastric Cancer.

Mark S McClain, Amber C Beckett, Timothy L Cover

Abstract readReview
In one paragraph

Review in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Helicobacter pylori Infection and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Prospective Study and Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Managing dangerous liaisons: lessons fromJournal of bacteriology · 2026
    Review
  6. Article
  7. Review
  8. Characterization ofFrontiers in microbiology · 2026
    Article
  9. Update on the pathogenesis and clinical management ofWorld journal of gastrointestinal pathophysiology · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Taurine modulates host cell responses toInfection and immunity · 2024
    Article
  16. Helicobacter pylori cagA, vacA, and iceA genotypes and clinical outcomes: a cross-sectional study in central Vietnam.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  17. Article
  18. Sustained exposure to Helicobacter pylori induces immune tolerance by desensitizing TLR6.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024
    Article
  19. Helicobacter pylori upregulates circPGD and promotes development of gastric cancer.Journal of cancer research and clinical oncology · 2024
    Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mark S McClainDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. mark.s.mcclain@vanderbilt.edu.
Amber C BeckettDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. amber.beckett@vanderbilt.edu.
Timothy L CoverDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. timothy.l.cover@vanderbilt.edu.

Funding

Role of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2009 to 2026
$27.5M
Structure-function analysis of H. pylori VacAR01AI039657 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TIMOTHY L COVER · 1996 to 2026
$8.3M
Type IV Protein Secretion in Helicobacter pyloriR01AI118932 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COVER, TIMOTHY L, OHI, MELANIE DIANE · 2016 to 2025
$6.7M
Pathogenesis of Helicobacter pylori infectionI01BX000627 · VA · VETERANS HEALTH ADMINISTRATION · PI COVER, TIMOTHY L · 2011 to 2018
–
BLRD VA I01 BX000627NCI NIH HHS P01 CA116087NIAID NIH HHS R01 AI039657NIAID NIH HHS R01 AI118932
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ProteinsHelicobacter pyloriAllelesAnimalsDisease Models, AnimalHumansRisk FactorsStomachStomach NeoplasmsVirulenceBacterial ProteinsVacA protein, Helicobacter pylorigastric cancerHelicobacter pyloripore-forming toxins

Identifiers

PMID29023421
PMCPMC5666363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.