Evidence map›Paper›PMID 29023371›Full record

ArticleViruses2017

Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4⁺ T Cells.

Alexandra Tremblay-McLean, Julie Bruneau, Bertrand Lebouché, Irene Lisovsky, Rujun Song, Nicole F Bernard

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. TIGIT Blockade: A Multipronged Approach to Target the HIV Reservoir.Frontiers in cellular and infection microbiology · 2020
    Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alexandra Tremblay-McLeanResearch Institute of the McGill University Health Center, Montréal, QC H4A 3J1, Canada. alexandra.tremblay-mclean@mail.mcgill.ca.
Julie BruneauDépartment de Médecine Familiale et Médecine D'urgence, Université de Montréal, Montréal, QC H2X 0A9, Canada. julie.bruneau.umontreal@gmail.com.
Bertrand LebouchéResearch Institute of the McGill University Health Center, Montréal, QC H4A 3J1, Canada. bertrand.lebouche@mcgill.ca.
Irene LisovskyResearch Institute of the McGill University Health Center, Montréal, QC H4A 3J1, Canada. lisovsky18@gmail.com.
Rujun SongResearch Institute of the McGill University Health Center, Montréal, QC H4A 3J1, Canada. rujun.song@mail.mcgill.ca.
Nicole F BernardResearch Institute of the McGill University Health Center, Montréal, QC H4A 3J1, Canada. nicole.bernard@mcgill.ca.
McGill University Health Centre · CAMcGill University · CAUniversité de Montréal · CA

Funding

CIHR MOP-142494
6 · The paper itself

Abstract

Natural Killer (NK) cell responses to HIV-infected CD4 T cells (iCD4) depend on the integration of signals received through inhibitory (iNKR) and activating NK receptors (aNKR). iCD4 activate NK cells to inhibit HIV replication. HIV infection-dependent changes in the human leukocyte antigen (HLA) ligands for iNKR on iCD4 are well documented. By contrast, less is known regarding the HIV infection related changes in ligands for aNKR on iCD4. We examined the aNKR ligand profiles HIV p24⁺ HIV iCD4s that maintained cell surface CD4 (iCD4⁺), did not maintain CD4 (iCD4

Indexed as

CD4-Positive T-LymphocytesHistocompatibility Antigens Class IHIV-1HLA AntigensHumansIntercellular Adhesion Molecule-1Killer Cells, NaturalLigandsNK Cell Lectin-Like Receptor Subfamily KReceptors, Natural Killer CellHistocompatibility Antigens Class IHLA AntigensHLA-F antigensIntercellular Adhesion Molecule-1LigandsMHC class I-related chain ANK Cell Lectin-Like Receptor Subfamily KReceptors, Natural Killer Cellactivating NK cell receptor ligandsHIV-infected CD4+ T cellsHIV infectionnatural killer cells

Identifiers

PMID29023371
PMCPMC5691646
OpenAlexW2761729382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.