ArticleRNA biology2018
Distinct transcriptional and processing regulations control miR167a level in tomato during stress.
Article in RNA biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- The miR167-ARF8 module coordinates stamen-pistil development and fruit set in tomato.The New phytologist · 2026Article
- Non-coding RNAs in plant stress responses: molecular insights and agricultural applications.Plant biotechnology journal · 2025Review
- DRB1 and DRB2 Are Required for an Appropriate miRNA-Mediated Molecular Response to Salt Stress inPlants (Basel, Switzerland) · 2025Article
- Genome-wide analysis of non-coding RNA reveals the role of a novel miR319c for tuber dormancy release process in potato.Horticulture research · 2025Article
- microRNAs: Key Regulators in Plant Responses to Abiotic and Biotic Stresses via Endogenous and Cross-Kingdom Mechanisms.International journal of molecular sciences · 2024Review
- Combined lncRNA and mRNA Expression Profiles Identified the lncRNA-miRNA-mRNA Modules Regulating the Cold Stress Response inInternational journal of molecular sciences · 2023Article
- The genome-wide characterization ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Article
- Impact of Nanomaterials on the Regulation of Gene Expression and Metabolomics of Plants under Salt Stress.Plants (Basel, Switzerland) · 2022Review
- miRNAs and lncRNAs in tomato: Roles in biotic and abiotic stress responses.Frontiers in plant science · 2022Review
- Regulation of pri-MIRNA processing: mechanistic insights into the miRNA homeostasis in plant.Plant cell reports · 2021Review
- Combined Stress Conditions in Melon Induce Non-additive Effects in the Core miRNA Regulatory Network.Frontiers in plant science · 2021Article
- Small RNAs: The Essential Regulators in Plant Thermotolerance.Frontiers in plant science · 2021Review
- Identification and Functional Characterization of Plant MiRNA Under Salt Stress Shed Light on Salinity Resistance Improvement Through MiRNA Manipulation in Crops.Frontiers in plant science · 2021Review
- Genome-wide identification of Arabidopsis long noncoding RNAs in response to the blue light.Scientific reports · 2020Article
- miRNA-mediated regulation of auxin signaling pathway during plant development and stress responses.Journal of biosciences · 2020Review
- Divergent molecular and growth responses of young "Cabernet Sauvignon" (Horticulture research · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Besides their definite role in plant developmental processes miR167 also serve as mediator of stress response. Although differential expression of miR167 occurs during stresses, the regulatory-mechanism of biogenesis remained elusive. Therefore, using tomato as the model plant we have explored the mechanism of regulation of miR167a expression during stresses. Fungus or virus infections and exposure to cold stress raised the level of miR167a expression. Whereas, salt, drought and heat treatments resulted in the downregulation, indicating different stresses activated alternative mechanisms for miR167a regulation. Interestingly, the relative expression level of precursors in control versus temperature stressed plants differed from the pattern observed in the mature miR167a expression, suggesting that both transcriptional and processing regulation were important for biogenesis. The promoter-regulatory sequence of the major isoform MIR167a harbours several development and stress-related regulatory sites. Accordingly, promoter assays using transient transformation and transgenic tobacco plants proved stress-dependent regulation of the promoter. Further analyses corroborated the role of tomato DREB2A protein in the transcriptional regulation during temperature stress. Finally, in vitro assays established the importance of processing factors in cold-stress dependent efficient processing of MIR167a precursors. These data confirm distinct role of transcriptional and processing machinery in stress-influenced regulation of tomato miR167a biogenesis.
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