Evidence map›Paper›PMID 29022902›Full record

ArticleCell death & disease2017

Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis.

Feifei Kong, Mei Wang, Xiaojing Huang, Qiuling Yue, Xiang Wei, Xiaowei Dou, Xiaoxu Peng, Yuanyuan Jia, Ke Zheng, Tinghe Wu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. LKB1 biology: assessing the therapeutic relevancy of LKB1 inhibitors.Cell communication and signaling : CCS · 2024
    Review
  4. Article
  5. Review
  6. Duplications in 19p13.3 are associated with male infertility.Journal of assisted reproduction and genetics · 2019
    Article
  7. AMPK Function in Mammalian Spermatozoa.International journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Feifei KongState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Mei WangState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Xiaojing HuangState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210008, China.
Qiuling YueState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Xiang WeiState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Xiaowei DouState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Xiaoxu PengState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Yuanyuan JiaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Ke ZhengState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.ORCID 0000-0001-9762-6605
Tinghe WuDepartment of Biotechnology and Biomedicine, Yangtze Delta Region Institutes of Tsinghua University, Jiaxing 314006, China.
Jun YanState Key Laboratory of Pharmaceutical Biotechnology and MOE Key Laboratory of Model Animals for Disease Study, Model Animal Research Center, Nanjing University, Nanjing 210008, China.
Jing LiState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China.
Nanjing Medical University · CNModel Animal Research Center · CNTsinghua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver serine/threonine kinase B1 (LKB1) is a tumor suppressor associated with the pathogenesis of Peutz-Jeghers syndrome. Affected males are at increased risk of developing Sertoli cell tumors and display defective spermatogenesis. Male mice lacking the short isoform (Lkb1

Indexed as

AcrosomeAdult Germline Stem CellsAMP-Activated Protein KinasesAnimalsCell DifferentiationInfertility, MaleIsoenzymesMaleMechanistic Target of Rapamycin Complex 1Membrane Potential, MitochondrialMiceMice, Inbred C57BLMice, KnockoutMitochondriaProtein Serine-Threonine KinasesSirolimusAMP-Activated Protein KinasesIsoenzymesMechanistic Target of Rapamycin Complex 1Protein Serine-Threonine KinasesSirolimusStk11 protein, mouse

Identifiers

PMID29022902
PMCPMC5682689
OpenAlexW2762789481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.