ArticleAnnals of the Royal College of Surgeons of England2018
Current predictive models do not accurately differentiate between single and multi gland disease in primary hyperparathyroidism: a retrospective cohort study of two endocrine surgery units.
Article in Annals of the Royal College of Surgeons of England, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 31 citations in OpenAlex.
- Clinical outcomes of parathyroidectomy in primary hyperparathyroidism: a 10-year single-center experience with 115 procedures.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Serum Biomarker-Based Diagnostic Tools for Primary Hyperparathyroidism: A Systematic Review and Meta-Analysis with Implications for Primary Care.Healthcare (Basel, Switzerland) · 2026Review
- Correlation between preoperative biochemical indices and intraoperative findings in primary hyperparathyroidism.Gland surgery · 2026Article
- Design of Nanostructured Enzyme Immobilized Platforms for Precise Diagnosis and Treatment of Endocrine Disease: An Updated Review.International journal of nanomedicine · 2026Review
- Machine learning-derived clinical decision algorithm for the diagnosis of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism.European radiology · 2025Article
- Article
- Primary hyperparathyroidism: predictors of sporadic multi-gland disease.Endocrine connections · 2024Review
- An Ectopic Parathyroid Adenoma of the Retropharynx in a Patient with Primary Hyperparathyroidism and Papillary Thyroid Cancer-A Rare Case.Diagnostics (Basel, Switzerland) · 2024Article
- A contemporary analysis of the pre- and intraoperative recognition of multigland parathyroid disease.Langenbeck's archives of surgery · 2023Review
- Adrenal Incidentalomas and Other Endocrine-Related Adenomas: How Much Does Cortisol Secretion Matter?Cancers · 2023Article
- Primary hyperparathyroidism in pregnancy: experience of a tertiary centre.Surgery today · 2023Article
- Predicting multigland disease in primary hyperparathyroidism using ultrasound and clinical features.Frontiers in endocrinology · 2023Article
- Multiglandular Parathyroid Disease.Life (Basel, Switzerland) · 2022Article
- Contribution of intraoperative parathyroid hormone monitoring to the surgical success in minimal invasive parathyroidectomy.Frontiers in surgery · 2022Article
- Artificial intelligence-augmented, label-free molecular imaging method for tissue identification, cancer diagnosis, and cancer margin detection.Biomedical optics express · 2021Article
- Usefulness of the Wisconsin and CaPTHUS indices for predicting multiglandular disease in patients with primary hyperparathyroidism in a southern European population.Gland surgery · 2021Article
- Intravagal parathyroid adenomas: Case report and literature review.Clinical case reports · 2020Article
- Stepwise Approach for Parathyroid Localisation in Primary Hyperparathyroidism.World journal of surgery · 2020Article
- Identification of key regulators in parathyroid adenoma using an integrative gene network analysis.Bioinformation · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Minimally invasive parathyroidectomy (MIP) for primary hyperparathyroidism is dependent upon accurate prediction of single-gland disease on the basis of preoperative imaging and biochemistry. The aims of this study were to validate currently available predictive models of single-gland disease in two UK cohorts and to determine if these models can facilitate MIP. Methods This is a retrospectively cohort study of 624 patients who underwent parathyroidectomy for primary hyperparathyroidism in two centres between July 2008 and December 2013. Two recognised models: CaPTHUS (preoperative calcium, parathyroid hormone, ultrasound, sestamibi, concordance imaging) and Wisconsin Index (preoperative calcium, parathyroid hormone) were validated for their ability to predict single-gland disease. Results The rates of single- and multi-gland disease were 491 (79.6%) and 126 (20.2%), respectively. Cure rates in centres 1 and 2 were 93.2% and 93.8%, respectively (P = 0.789). The positive predictive value (PPV) of CaPTHUS score . 3 in predicting single-gland disease was 84.6%, compared with 100% in the original report. CaPTHUS . 4 and 5 had a PPV of 85.1 and 87.1, respectively. There were no differences in Wisconsin Index (WIN) between patients with single- and multi-gland (P = 0.573). A WIN greater than 1600 and weight of excised gland greater than 1 g had a positive predictive value of 86.7% for single-gland disease. Conclusions The use of CaPTHUS and WIN indices without intraoperative adjuncts (such as IOPTH) had the potential to result in failure to cure in up to 15% (CaPTHUS) and 13% (WIN) of patients treated by MIP targeting a single enlarged gland.
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