ReviewNature reviews. Disease primers2017
Syphilis.
Review in Nature reviews. Disease primers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 290 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
290 citing papers in PubMed, 11 syntheses or guidelines pooled it, 611 citations in OpenAlex.
- An integrated immunopathological model of syphilis serofast: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Medicinal Plants Used for Combating Human Bacterial Diseases in Ethiopia: A Systematic Review.TheScientificWorldJournal · 2026Pooled it
- Effectiveness of treating gestational syphilis in the last trimester on the incidence of congenital syphilis: a systematic review and meta-analysisRevista colombiana de obstetricia y ginecologia · 2025Pooled it
- A systematic review and meta-analysis of the prevalence and risk of syphilis among blood donors in Thailand.Scientific reports · 2025Pooled it
- Reinfection caused by gestational syphilis: A case report and systematic review of the literatureRevista colombiana de obstetricia y ginecologia · 2025Pooled it
- Global research trends in neurosyphilis: a bibliometric analysis from 2010 to 2024.Frontiers in immunology · 2025Pooled it
- Risk factors of serofast state in patients undergoing syphilis: a meta-analysis of 17 cohort studies.Frontiers in immunology · 2025Pooled it
- Prevalence of gonococcal and chlamydial infections among men who have sex with men in sub-Saharan Africa: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Neurosyphilis-Induced Psychosis in Europe: A Systematic Review of Case Reports.Pathogens (Basel, Switzerland) · 2024Pooled it
- Computational methods applied to syphilis: where are we, and where are we going?Frontiers in public health · 2023Pooled it
- IL-10 and IL-17 as Progression Markers of Syphilis in People Living with HIV: A Systematic Review.Biomolecules · 2022Pooled it
- Jarisch-Herxheimer Reaction After Benzathine Penicillin G Treatment in Adults With Early Syphilis: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2025Trial
- "So much other stuff going on": Factors influencing syphilis and STBBI testing among street-involved communities in Kingston, Ontario.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Iberian Registry of Ocular Syphilis (IBERSOS) report 1: epidemiology, clinical spectrum and treatment outcomes of ocular syphilis in the Iberian Peninsula.The British journal of ophthalmology · 2026Observational
- Molecular and serological evidence of systemiciScience · 2026Article
- German guideline on neurosyphilis.Neurological research and practice · 2026Review
- Antiphospholipid antibodies in acute and post-treatment Lyme disease.Infection and immunity · 2026Article
- Review
- Estimating the Value of Novel Tests for Active Syphilis in Zimbabwe: How Much Overtreatment Can Be Avoided?Sexually transmitted diseases · 2026Article
- Socio-Demographic and Prenatal Care Factors Associated with TORCH Screening During Pregnancy in Romania: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
230 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 6 institutions in 4 countries.
Funding
Abstract
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. T. pallidum is renowned for its invasiveness and immune-evasiveness; its clinical manifestations result from local inflammatory responses to replicating spirochaetes and often imitate those of other diseases. The spirochaete has a long latent period during which individuals have no signs or symptoms but can remain infectious. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Syphilis also causes several hundred thousand stillbirths and neonatal deaths every year in developing nations. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen. Strong advocacy and community involvement are needed to ensure that syphilis is given a high priority on the global health agenda. More investment is needed in research on the interaction between HIV and syphilis in MSM as well as into improved diagnostics, a better test of cure, intensified public health measures and, ultimately, a vaccine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.