Evidence map›Paper›PMID 29022550›Full record

ArticleJournal of medical microbiology2017

Streptococcus gordonii pheromone s.g.cAM373 may influence the reservoir of antibiotic resistance determinants of Enterococcus faecalis origin in the oral metagenome.

Jillian M Mansfield, Paul Herrmann, Amy M Jesionowski, M Margaret Vickerman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. The Distribution of Eight Antimicrobial Resistance Genes inTropical medicine and infectious disease · 2023
    Article
  3. Review
  4. Bacteria ModifymSphere · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jillian M MansfieldDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA.
Paul HerrmannDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA.
Amy M JesionowskiDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA.
M Margaret VickermanDepartment of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, NY 14214, USA.
University at Buffalo, State University of New York · US

Funding

Amylase binding and gene expression in S. gordoniiR01DE022673 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI SCANNAPIECO, FRANK ANDREW · 2012 to 2016
$2.6M
Oral streptococcal-enterococcal peptide-mediated intercellular communicationR21DE022154 · NIDCR · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI VICKERMAN, M MARGARET · 2011 to 2012
$436k
NIDCR NIH HHS R01 DE022673NIDCR NIH HHS R21 DE022154
6 · The paper itself

Abstract

Streptococcus gordonii produces a pheromone heptapeptide, s.g.cAM373, which induces a conjugative mating response in Enterococcus faecalis cells carrying the responsive plasmid, pAM373. We investigated the extent of this intergeneric signaling on DNA acquisition by streptococcal species likely to cohabit oral biofilms. E. faecalis/pAM373/pAMS470 cells were incubated with synthetic s.g.cAM373, reverse peptide s.g.cAM373-R, or peptide-free medium and examined for their abilities to transfer plasmid DNA to streptococcal species in the presence of DNase. Preinduction of E. faecalis donors with s.g.cAM373 resulted in transconjugation frequencies in non-pheromone producing strains of Streptococcus mutans, Streptococcus sanguinis, Streptococcus anginosus, and Streptococcus suis that were significantly higher than frequencies when donors were preincubated with s.g.cAM373-R or medium alone. Peptide-mediated communication between commensal streptococci and E. faecalis carrying pheromone-responsive plasmids may facilitate conjugative DNA transfer to bystander species, and influence the reservoir of antibiotic resistance determinants of enterococcal origin in the oral metagenome.

Indexed as

Anti-Bacterial AgentsBacterial ProteinsConjugation, GeneticDNA, BacterialDrug Resistance, BacterialEnterococcus faecalisGene Expression Regulation, BacterialGenome, BacterialMetagenomePheromonesStreptococcus gordoniiAnti-Bacterial AgentsBacterial ProteinsDNA, BacterialPheromonesantibiotic resistancebiofilmcommensal streptococciEnterococcus faecalisoral microbiologypheromoneplasmid transfersignaling

Identifiers

PMID29022550
PMCPMC7001488
OpenAlexW2760907134

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.