Evidence map›Paper›PMID 29022127›Full record

ArticleThe international journal of cardiovascular imaging2018

Genetic influence on femoral plaque and its relationship with carotid plaque: an international twin study.

Pierleone Lucatelli, Corrado Fagnani, Adam Domonkos Tarnoki, David Laszlo Tarnoki, Beatrice Sacconi, Bence Fejer, Maria Antonietta Stazi, Miriam Salemi, Carlo Cirelli, Alessandro d'Adamo and 13 more

Abstract readMulticenter StudyTwin Study
PubMed Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 2 countries.

Pierleone LucatelliVascular and Interventional Radiology Unit, Department of Radiology, Oncology and Anatomic Pathology, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. pierleone.lucatelli@gmail.com.ORCID http://orcid.org/0000-0002-7448-1404
Corrado FagnaniCentre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Adam Domonkos TarnokiDepartment of Radiology, Semmelweis University, Budapest, Hungary.
David Laszlo TarnokiDepartment of Radiology, Semmelweis University, Budapest, Hungary.
Beatrice SacconiVascular and Interventional Radiology Unit, Department of Radiology, Oncology and Anatomic Pathology, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Bence FejerDepartment of Radiology, Semmelweis University, Budapest, Hungary.
Maria Antonietta StaziCentre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Miriam SalemiCentre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Carlo CirelliVascular and Interventional Radiology Unit, Department of Radiology, Oncology and Anatomic Pathology, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Alessandro d'AdamoVascular and Endovascular Surgery Division, Department of Surgery "Paride Stefanini", Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Fabrizio FanelliVascular and Interventional Radiology Unit, Department of Radiology, Oncology and Anatomic Pathology, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Carlo CatalanoVascular and Interventional Radiology Unit, Department of Radiology, Oncology and Anatomic Pathology, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Pal Maurovich-HorvatMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Adam L JermendyMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Gyorgy Jermendy3rd Department of Internal Medicine, Bajcsy Zsilinszky Hospital, Budapest, Hungary.
Bela MerkelyMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Andrea A MolnarMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Giacomo PucciUnità di Medicina Interna, Ospedale 'S. Maria', Università di Perugia, Terni, Italy.
Giuseppe SchillaciUnità di Medicina Interna, Ospedale 'S. Maria', Università di Perugia, Terni, Italy.
Filippo FarinaDepartment of Neurosciences, University of Padua School of Medicine, Padua, Italy.
Giorgio MeneghettiDepartment of Neurosciences, University of Padua School of Medicine, Padua, Italy.
Claudio BaracchiniDepartment of Neurosciences, University of Padua School of Medicine, Padua, Italy.
Emanuela MeddaCentre for Behavioural Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Semmelweis University · HUPoliclinico Umberto I · ITIstituto Superiore di Sanità · ITUniversity of Padua · ITBajcsy-Zsilinszky Kórház és Rendelőintézet · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To disentangle genetic and environmental influences on the development of femoral plaques using a population of adult twins. To evaluate the potential role of shared genetic and environmental factors in the co-occurrence of femoral and carotid plaques. The sample included 566 twins belonging to 164 monozygotic (MZ) and 119 dizygotic (DZ) twin pairs, who underwent peripheral arterial assessment by B-mode ultrasound in different centers. The variance in femoral plaques onset was due to genetic factors and the remaining 50% was explained by common (15%) and unique (35%) environmental factors. Findings on sidedness and number of femoral plaques indicated that also these traits were mainly under genetic control. No effect of common environment was found on plaques composition, and variability of this trait was explained by genetics (64%) and unique environment (36%). Covariation between the liabilities to carotid and femoral plaques was mainly attributed to shared genes (77%), with the remaining 23% explained by individual-specific environmental factors shared by the two districts. Inter-individual differences in plaque onset as well as in their number, sidedness and composition are mainly genetic in origin. The results on the cooccurrence of carotid and femoral plaque underline the genetic role in atherogenesis.

Indexed as

Gene-Environment InteractionPlaque, AtheroscleroticAdultAgedCarotid ArteriesCarotid Artery DiseasesCarotid Intima-Media ThicknessFemaleFemoral ArteryHumansHungaryItalyMaleMiddle AgedPeripheral Arterial DiseaseRisk FactorsAtherosclerosisCarotid artery plaqueFemoral artery plaqueGeneticTwin studies

Identifiers

PMID29022127
OpenAlexW2764208406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.