Evidence map›Paper›PMID 29022125›Full record

Trial reportJournal of autism and developmental disorders2018

Parent Stress in a Randomized Clinical Trial of Atomoxetine and Parent Training for Children with Autism Spectrum Disorder.

Luc Lecavalier, Xueliang Pan, Tristram Smith, Benjamin L Handen, L Eugene Arnold, Laura Silverman, Rameshwari V Tumuluru, Jill Hollway, Michael G Aman

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of autism and developmental disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00844753 (Atomoxetine, Placebo and Parent Management Training in Autism), which is not on this map. Cited by 4 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 4 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00844753 phase4completednot on this map

Atomoxetine, Placebo and Parent Management Training in Autism

TypeinterventionalSponsorUniversity of RochesterRan2008 to 2014Enrolled128ConditionsAutism, Pervasive Development Disorder, Asperger's Disorder, Attention Deficit Hyperactivity DisorderArmsatomoxetine, Placebo, Parent Management Training
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Luc LecavalierNisonger Center and Department of Psychology, Ohio State University, 371D McCampbell Hall, 1581 Dodd Dr., Columbus, OH, 43210, USA. Luc.Lecavalier@Osumc.edu.ORCID 0000-0002-1162-659X
Xueliang PanCenter for Biostatistics, Department of Biomedical Informatics, Ohio State University, 371D McCampbell Hall, 1581 Dodd Dr., Columbus, OH, 43210, USA.
Tristram SmithUniversity of Rochester Medical Center (URMC), 601 Elmwood Ave, Box 671, Rochester, NY, 14642, USA.
Benjamin L HandenWestern Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA, 15213, USA.
L Eugene ArnoldNisonger Center and Department of Psychiatry, Ohio State University, 285B McCampbell Hall, 1581 Dodd Drive, Columbus, OH, 43210, USA.
Laura SilvermanUniversity of Rochester Medical Center (URMC), 601 Elmwood Ave, Box 671, Rochester, NY, 14642, USA.
Rameshwari V TumuluruWestern Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St., Pittsburgh, PA, 15213, USA.
Jill HollwayNisonger Center and Department of Psychiatry, Ohio State University, 285B McCampbell Hall, 1581 Dodd Drive, Columbus, OH, 43210, USA.
Michael G AmanNisonger Center and Department of Psychology, Ohio State University, 371D McCampbell Hall, 1581 Dodd Dr., Columbus, OH, 43210, USA.
The Ohio State University · USUniversity of Pittsburgh · USUniversity of Rochester Medical Center · US

Funding

2/3-Atomoxetine Placebo and Parent Training in AutismR01MH079080 · NIMH · OHIO STATE UNIVERSITY · PI AMAN, MICHAEL GEORGE · 2008 to 2012
$1.8M
3/3-Atomoxetine Placebo and Parent Training in AutismR01MH083247 · NIMH · UNIVERSITY OF ROCHESTER · PI SMITH, TRISTRAM H · 2008 to 2012
$1.4M
1/3-Atomoxetine Placebo and Parent Training in AutismR01MH079082 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L · 2008 to 2012
$1.4M
NIMH NIH HHS R01 MH079080NIMH NIH HHS R01 MH079082NIMH NIH HHS R01MH079082-01A2NIMH NIH HHS R01 MH083247
6 · The paper itself

Abstract

We previously reported a 2 × 2 randomized clinical trial of atomoxetine (ATX) and parent training (PT) for attention deficit hyperactivity disorder (ADHD) symptoms and behavioral noncompliance in 128 children with autism spectrum disorder, ages 5-14 years. Children were randomized to one of four conditions: ATX alone, placebo alone, ATX + PT, or PT + placebo. Both ATX and PT improved some indices of ADHD and behavioral compliance. In this report, we describe parent stress over time and across conditions. All four treatments improved parent self-rated stress from baseline to week 10. However, there were no statistically significant differences between treatment groups. Significantly more improvement in parent stress scores was observed for clinical responders than non-responders. ClinicalTrials.gov Title: Atomoxetine, Placebo and Parent Management Training in Autism (Strattera) ClinicalTrials.gov Identifier: NCT00844753.

Indexed as

Stress, PsychologicalAdolescentAdrenergic Uptake InhibitorsAdultAtomoxetine HydrochlorideAutism Spectrum DisorderChildChild, PreschoolDouble-Blind MethodFemaleHumansMaleMiddle AgedParentsTreatment OutcomeAdrenergic Uptake InhibitorsAtomoxetine HydrochlorideAtomoxetineAttention deficit hyperactivity disorderAutism spectrum disorderParent stressParent training

Identifiers

PMID29022125
PMCPMC6070148
OpenAlexW2761971158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.