ArticlePsychopharmacology2018
Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats.
Article in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Chronic ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Effectiveness of cannabidiol (CBD) on histopathological changes and gene expression in hepatocellular carcinoma (HCC) model in male rats: the role of Hedgehog (Hh) signaling pathway.Histochemistry and cell biology · 2024Article
- Mechanisms of cannabinoid tolerance.Biochemical pharmacology · 2023Review
- Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats.Psychopharmacology · 2023Article
- Alcohol and cannabinoid binges and daily exposure to nicotine in adolescent/young adult rats induce sex-dependent long-term appetitive instrumental learning impairment.Frontiers in behavioral neuroscience · 2023Article
- Adolescent THC exposure: effects on pain-related, exploratory, and consummatory behaviors in adult male vs. female rats.Psychopharmacology · 2022Article
- Pharmacokinetic and pharmacodynamic properties of aerosolized ("vaped") THC in adolescent male and female rats.Psychopharmacology · 2021Article
- Δ 9-Tetrahydrocannabinol During Adolescence Reprograms the Nucleus Accumbens Transcriptome, Affecting Reward Processing, Impulsivity, and Specific Aspects of Cocaine Addiction-Like Behavior in a Sex-Dependent Manner.The international journal of neuropsychopharmacology · 2021Article
- Persistent Exposure to ΔThe Journal of pharmacology and experimental therapeutics · 2021Article
- Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics.Current neuropharmacology · 2021Article
- Discordant Effects of Cannabinoid 2 Receptor Antagonism/Inverse Agonism During Adolescence on Pavlovian and Instrumental Reward Learning in Adult Male Rats.Frontiers in synaptic neuroscience · 2021Article
- Neural and behavioral correlates associated with adolescent marijuana use.Current addiction reports · 2020Article
- Compulsivity is measurable across distinct psychiatric symptom domains and is associated with familial risk and reward-related attentional capture.CNS spectrums · 2020Article
- Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice.Science advances · 2020Article
- Reward-related attentional capture is associated with severity of addictive and obsessive-compulsive behaviors.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Article
- Voluntary oral consumption of ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Excessive Consumption of Sugar: an Insatiable Drive for Reward.Current nutrition reports · 2019Review
- Article
- Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia.Psychopharmacology · 2018Article
- Cannabinoid Delivery Systems for Pain and Inflammation Treatment.Molecules (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
rationaleAdolescence is characterized by endocannabinoid (ECB)-dependent refinement of neural circuits underlying emotion, learning, and motivation. As a result, adolescent cannabinoid receptor stimulation (ACRS) with phytocannabinoids or synthetic agonists like "Spice" cause robust and persistent changes in both behavior and circuit architecture in rodents, including in reward-related regions like medial prefrontal cortex and nucleus accumbens (NAc). OBJECTIVES AND
methodsHere, we examine persistent effects of ACRS with the cannabinoid receptor 1/2 specific agonist WIN55-212,2 (WIN; 1.2 mg/kg/day, postnatal day (PD) 30-43), on natural reward-seeking behaviors and ECB system function in adult male Long Evans rats (PD 60+).
resultsWIN ACRS increased palatable food intake, and altered attribution of incentive salience to food cues in a sign-/goal-tracking paradigm. ACRS also blunted hunger-induced sucrose intake, and resulted in increased anandamide and oleoylethanolamide levels in NAc after acute food restriction not seen in controls. ACRS did not affect food neophobia or locomotor response to a novel environment, but did increase preference for exploring a novel environment.
conclusionsThese results demonstrate that ACRS causes long-term increases in natural reward-seeking behaviors and ECB system function that persist into adulthood, potentially increasing liability to excessive natural reward seeking later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.