SynthesisWorld journal of surgery2018
Esophagectomy for End-Stage Achalasia: Systematic Review and Meta-analysis.
Synthesis in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Robotic versus laparoscopic heller myotomy for esophageal achalasia: an updated systematic review and meta-analysis.Langenbeck's archives of surgery · 2025Pooled it
- Total extraperitoneal (TEP) versus laparoscopic transabdominal preperitoneal (TAPP) hernioplasty: systematic review and trial sequential analysis of randomized controlled trials.Hernia : the journal of hernias and abdominal wall surgery · 2021Pooled it
- Treatment of achalasia in the bariatric surgery population: a systematic review and single-institution experience.Surgical endoscopy · 2021Pooled it
- Diaphragmatic herniation after esophagogastric surgery: systematic review and meta-analysis.Langenbeck's archives of surgery · 2021Pooled it
- ACG Clinical Guidelines: Diagnosis and Management of Achalasia.The American journal of gastroenterology · 2020Guideline
- European guidelines on achalasia: United European Gastroenterology and European Society of Neurogastroenterology and Motility recommendations.United European gastroenterology journal · 2020Guideline
- Minimally invasive surgical management of mid- to distal esophageal diverticula: a large single-center review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2026Article
- Modern treatment for achalasia: endoscopic and surgical therapies.The British journal of surgery · 2026Review
- Robotic vs. laparoscopic Ivor Lewis esophagectomy for esophageal cancer: a weighted short- and long-term outcomes analysis.Surgical endoscopy · 2026Article
- Intraoperative Hemodynamic Management During Esophagectomy and Implications for Postoperative Care.Journal of the American College of Surgeons · 2026Article
- Histological Predictors of Anastomotic Stenosis in Esophageal Substitution Surgery.Clinical medicine & research · 2026Article
- Real-world management of achalasia and esophagogastric junction outlet obstruction in Italy: results from a national survey.Updates in surgery · 2025Article
- Safety, efficacy, and patient satisfaction after esophagectomy for esophageal neuromotor disease: A single-institution experience.JTCVS open · 2025Article
- Robotic stapled cardioplasty, an alternative before esophagectomy.Updates in surgery · 2025Article
- Outcomes of esophagectomy in patients with previous foregut surgery: a matched retrospective cohort study.Surgical endoscopy · 2025Article
- Efficacy of laparoscopic cardiectomy combined with side overlap anastomosis for the treatment of terminal achalasia.Scientific reports · 2025Article
- Terminal Stage of Esophageal Achalasia Combined With Adenocarcinoma After a Previous Open Myotomy.Cureus · 2025Article
- State-of-the-Art Surgery in Achalasia.Visceral medicine · 2024Review
- Association of operative time and approach on postoperative complications for esophagectomy.Surgery · 2024Article
- Esophageal Per-Oral Endoscopic Myotomy (E-POEM): Future Directions and Perspectives.Current gastroenterology reports · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndications for surgery and clinical outcomes of esophagectomy in the management of end-stage achalasia are not clearly defined. The aim of this systematic review and meta-analysis was to provide evidence-based information to help in the decision-making and in the choice of surgical technique.
methodsAn extensive literature search was conducted to identify all reports on esophagectomy for end-stage achalasia patients over the past three decades. MEDLINE, Embase and Cochrane databases were thoroughly consulted matching the terms "achalasia," "end-stage achalasia," "esophagectomy" and "esophageal resection" with "AND" and "OR." Short- and long-term outcome data were extracted. Pooled prevalence of pneumonia, anastomotic leakage and mortality were calculated using Freeman-Tukey double arcsine transformation and DerSimonian-Laird estimator in random effect meta-analysis. Heterogeneity among studies was evaluated using I
resultsEight papers published between 1989 and 2014 matched the inclusion criteria. In total, 1307 patients were included. Esophagectomy was performed through a transthoracic (78.7%) or a transhiatal (21.3%) approach. The stomach was used as an esophageal substitute in 95% of patients. Pooled prevalence of pneumonia, anastomotic leakage and mortality were 10% (95% CI 4-18%), 7% (95% CI 4-10%) and 2% (95% CI 1-3%), respectively.
conclusionsEsophagectomy for end-stage achalasia is safe and effective. Based on the results of this study, esophagectomy should be performed without hesitation in patients who are fit for major surgery and present with disabling symptoms, poor quality of life and dolichomegaesophagus recalcitrant to multiple endoscopic dilatations and/or surgical myotomies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.