Evidence map›Paper›PMID 29022053›Full record

ReviewInflammation research : official journal of the European Histamine Research Society ... [et al.]2018

Glycated albumin (GA) and inflammation: role of GA as a potential marker of inflammation.

H Vernon Roohk, Asad R Zaidi, Dimple Patel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Integrative Role of Albumin: Evolutionary, Biochemical and Pathophysiological Aspects.Journal of evolutionary biochemistry and physiology · 2021
    Article
  15. Albumin as a drug: its biological effects beyond volume expansion.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020
    Review
  16. Review of methods for detecting glycemic disorders.Diabetes research and clinical practice · 2020
    Review
  17. Review
  18. Article
  19. The Neonatal Fc Receptor (FcRn): A Misnomer?Frontiers in immunology · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

H Vernon RoohkDepartment of Surgery (Emeritus), University of California Irvine, Irvine, CA, USA.
Asad R ZaidiEpinex Diagnostics, Inc., 14351 Myford Road, Unit J, Tustin, CA, 92780, USA.
Dimple PatelEpinex Diagnostics, Inc., 14351 Myford Road, Unit J, Tustin, CA, 92780, USA. dimple@epinex.com.ORCID http://orcid.org/0000-0003-0235-5174
University of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAbnormal levels of glycated albumin (GA) are associated with the onset of both diabetes and inflammation. Although inflammation has long been associated with diabetes, this article aims to explore the underlying mechanisms of this relationship as it pertains to the role of GA.

methodsWe have reviewed 52 research articles since the year 2000. Common search terms used were "(inflammatory mediator) and GA" or "inflammation and GA". The findings have been organized according to diabetic complications with respect to the interactions of GA and inflammatory mediators. Glycated albumin and specific inflammatory mediators have been reported to play various roles in the pathogenesis of insulin resistance, atherosclerosis, coronary artery disease, retinopathy, and nephropathy. In the case of nephropathy and recently retinopathy, there is considerable evidence for GA in concert with inflammation playing a direct role in organ pathology. There is copious literature detailing GA's involvement in stimulating inflammatory markers and certain pro-inflammatory cytokines. A recent clinical study has shown GA to be a marker for inflammation in non-diabetic rheumatoid arthritis patients with the significance of standard inflammatory markers.

conclusionsThe clinical utility of GA measurement may likely reside in its versatility as both a mediator of inflammation as well as a marker to track hyperglycemia and other diabetes complications. Further understanding of the role GA plays in glycemic and inflammatory diseases could lead to its acceptance as an independent bio-inflammatory marker.

Indexed as

AnimalsArthritis, RheumatoidAtherosclerosisBiomarkersCoronary Artery DiseaseGlycated Serum AlbuminGlycation End Products, AdvancedHumansInflammationInsulin ResistanceKidney DiseasesRetinal DiseasesSerum AlbuminBiomarkersGlycated Serum AlbuminGlycation End Products, AdvancedSerum AlbuminGlycated albuminGlycated albumin point-of-care testInflammationInflammatory marker

Identifiers

PMID29022053
OpenAlexW2761068501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.