Evidence map›Paper›PMID 29022001›Full record

ArticleData in brief2017

Data supporting the functional role of Eleven-nineteen Lysine-rich Leukemia 3 (ELL3) in B cell lymphoma cell line cells.

Lou-Ella M M Alexander, January Watters, Jessica A Reusch, Michelle Maurin, Brook S Nepon-Sixt, Katerina Vrzalikova, Mark G Alexandrow, Paul G Murray, Kenneth L Wright

Abstract read
In one paragraph

Article in Data in brief, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lou-Ella M M AlexanderCancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33612, United States.
January WattersCancer Biology Ph.D. Program, University of South Florida, Tampa, FL 33612, United States.
Jessica A ReuschDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa FL33612, United States.
Michelle MaurinDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa FL33612, United States.
Brook S Nepon-SixtDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL33612, United States.
Katerina VrzalikovaInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Mark G AlexandrowDepartment of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL33612, United States.
Paul G MurrayInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom.
Kenneth L WrightDepartment of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa FL33612, United States.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Tumor Immunology Training Program -1 T32 CA115308-A1T32CA115308 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI WRIGHT, KENNETH LYNN · 2007 to 2017
$2.8M
Natural Killer Cell Regulation by PRDM1 and IRF4/8R01CA164641 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI WRIGHT, KENNETH LYNN · 2013 to 2017
$1.6M
NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA164641NCI NIH HHS T32 CA115308
6 · The paper itself

Abstract

The data presented here are related to the research article entitled "Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival" (Alexander et al., 2017) [1]. The cited research article characterizes Eleven-nineteen Lysine-rich Leukemia 3 (ELL3) expression in the B cell compartment and functional dependence in B lymphoma cell lines. This data report describes the mRNA expression pattern in a panel of cell lines representing the B cell compartment, supplementing the protein expression data presented in the associated research report. In addition, a reanalysis is presented of publicly available mRNA expression data from primary murine B cells to reveal dynamic regulation of the ELL family members post LPS stimulation (Barwick et al., 2016) [2]. The effect of ELL3 depletion on cell morphology, latent Epstein Barr Virus (EBV) lytic replication and differentiation markers in a Burkitt's lymphoma (BL) cell line cells are presented.

Indexed as

B-cell LymphomaBL, Burkitt's LymphomaCell divisionEBVEBV, Epstein Barr VirusELL3ELL, Eleven-nineteen Lysine-rich LeukemiaTranscription elongation

Identifiers

PMID29022001
PMCPMC5633249

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.