Evidence map›Paper›PMID 29021813›Full record

ArticleNutrition & metabolism2017

Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial.

Arrigo F G Cicero, Federica Fogacci, Martina Rosticci, Angelo Parini, Marina Giovannini, Maddalena Veronesi, Sergio D'Addato, Claudio Borghi

Erratum issued Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrition & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02603276 (Lipid-lowering Effect of Phytosterols, Red Yeast Rice and Their Combination in Moderately Hypercholesterolemic Subjects in Primary Prevention for Cardiovascular Diseases), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02603276 nacompletednot on this map

Lipid-lowering Effect of Phytosterols, Red Yeast Rice and Their Combination in Moderately Hypercholesterolemic Subjects in Primary Prevention for Cardiovascular Diseases: a Randomized, Double Blind, Clinical Trial

TypeinterventionalSponsorUniversity of BolognaRan2015 to 2015Enrolled60ConditionsHypercholesterolemiaArmsPlant sterols, Red Yeast Rice, Red Yeast Rice plus Plant sterols
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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  19. Latest Updates on Lipid Management.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Arrigo F G CiceroMedical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Federica FogacciMedical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Martina RosticciMedical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Angelo PariniMedical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Marina GiovanniniMedical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Maddalena VeronesiMedical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Sergio D'AddatoMedical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.
Claudio BorghiMedical and Surgical Sciences Department, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy.
University of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association.

methodsWe performed a three parallel arms, double blind, clinical trial randomizing 90 moderately hypercholesterolemic subjects to treatment with phytosterols 800 mg (group 1), red yeast rice standardized to contain 5 mg monacolins from

resultsAfter 8 weeks of treatment, in group 1 no significant variation of lipid parameters has been detected. In group 2 a significant reduction (

conclusionThe association of phytosterol and red yeast rice seems to have additive cholesterol lowering effect, reaching a clinically significant LDL-Cholesterol reduction in mildly hypercholesterolemic patients.

trial registrationClinicalTrial.gov ID: NCT02603276, Registered 27/08/2015.

Indexed as

Clinical trialLDL-cholesterolMonacolinsNutraceuticalsPhytosterolsRed yeast Rice

Identifiers

PMID29021813
PMCPMC5613479
OpenAlexW4250166675

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.