Evidence map›Paper›PMID 29021768›Full record

ArticleFrontiers in psychology2017

Endogenous Oxytocin, Vasopressin, and Aggression in Domestic Dogs.

Evan L MacLean, Laurence R Gesquiere, Margaret E Gruen, Barbara L Sherman, W Lance Martin, C Sue Carter

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Role of Major Biomarkers of Stress in Atrial Fibrillation: A Literature Review.The Journal of innovations in cardiac rhythm management · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Is Oxytocin "Nature's Medicine"?Pharmacological reviews · 2020
    Review
  15. Article
  16. Article
  17. Variability in Human-Animal Interaction Research.Frontiers in veterinary science · 2020
    Review
  18. Where Do We Stand in the Domestic Dog (Frontiers in psychology · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Evan L MacLeanSchool of Anthropology, University of Arizona, Tucson, AZ, United States.
Laurence R GesquiereDepartment of Biology, Duke University, Durham, NC, United States.
Margaret E GruenEvolutionary Anthropology, Duke University, Durham, NC, United States.
Barbara L ShermanDepartment of Clinical Sciences, NC State College of Veterinary Medicine, NC State University, Raleigh, NC, United States.
W Lance MartinMartin-Protean LLC, Princeton, NJ, United States.
C Sue CarterKinsey Institute and Department of Biology, Indiana University, Bloomington, IA, United States.
Duke University · USIndiana University Bloomington · USNorth Central State College · USUniversity of Arizona · US

Funding

ImagingP01HD075750 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI CARTER PORGES, CAROL SUE · 2014 to 2018
$4.3M
NICHD NIH HHS P01 HD075750
6 · The paper itself

Abstract

Aggressive behavior in dogs poses public health and animal welfare concerns, however the biological mechanisms regulating dog aggression are not well understood. We investigated the relationships between endogenous plasma oxytocin (OT) and vasopressin (AVP)-neuropeptides that have been linked to affiliative and aggressive behavior in other mammalian species-and aggression in domestic dogs. We first validated enzyme-linked immunosorbent assays (ELISAs) for the measurement of free (unbound) and total (free + bound) OT and AVP in dog plasma. In Experiment 1 we evaluated behavioral and neuroendocrine differences between a population of pet dogs with a history of chronic aggression toward conspecifics and a matched control group. Dogs with a history of aggression exhibited more aggressive behavior during simulated encounters with conspecifics, and had lower free, but higher total plasma AVP than matched controls, but there were no group differences for OT. In Experiment 2 we compared OT and AVP concentrations between pet dogs and a population of assistance dogs that have been bred for affiliative and non-aggressive temperaments, and investigated neuroendocrine predictors of individual differences in social behavior within the assistance dog population. Compared to pet dogs, assistance dogs had higher free and total OT, but there were no differences in either measure for AVP. Within the assistance dog population, dogs who behaved more aggressively toward a threatening stranger had higher total AVP than dogs who did not. Collectively these data suggest that endogenous OT and AVP may play critical roles in shaping dog social behavior, including aspects of both affiliation and aggression.

Indexed as

aggressionbehaviordogoxytocinvasopressin

Identifiers

PMID29021768
PMCPMC5624304
OpenAlexW2625059723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.