ArticleJournal of ginseng research2017
Melanogenesis inhibition activity of floralginsenoside A from
Article in Journal of ginseng research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Research progress on chemical diversity of saponins inChinese herbal medicines · 2024Review
- Therapeutic Applications of Ginseng Natural Compounds for Health Management.International journal of molecular sciences · 2023Review
- The Potential ofAntioxidants (Basel, Switzerland) · 2023Article
- In Vitro and In Vivo Antimelanogenesis Effects of Leaf Essential Oil fromPharmaceutics · 2023Article
- Anti-Melanogenic Potential of Natural and Synthetic Substances: Application in Zebrafish Model.Molecules (Basel, Switzerland) · 2023Review
- Natural products in cosmetics.Natural products and bioprospecting · 2022Review
- Plants as Modulators of Melanogenesis: Role of Extracts, Pure Compounds and Patented Compositions in Therapy of Pigmentation Disorders.International journal of molecular sciences · 2022Review
- Insights into Recent Studies on Biotransformation and Pharmacological Activities of Ginsenoside Rd.Biomolecules · 2022Review
- Anti-melanogenic property of ginsenoside Rf fromJournal of ginseng research · 2021Article
- Antimelanogenesis Effects of Leaf Extract and Phytochemicals from Ceylon Olive (Pharmaceutics · 2021Article
- Anti-Pigmentary Natural Compounds and Their Mode of Action.International journal of molecular sciences · 2021Review
- Modified Riceberry rice extract suppresses melanogenesis-associated cell differentiation through tyrosinase-mediated MITF downregulation on B16 cells andResearch in pharmaceutical sciences · 2020Article
- Advances in Saponin Diversity ofMolecules (Basel, Switzerland) · 2020Review
- Traditional Asian Herbs in Skin Whitening: The Current Development and Limitations.Frontiers in pharmacology · 2020Review
- Rice Bran Ash Mineral Extract Increases Pigmentation through the p-ERK Pathway in Zebrafish (International journal of molecular sciences · 2019Article
- Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish (International journal of molecular sciences · 2018Article
- Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae,International journal of molecular sciences · 2018Article
- A Zebrafish Embryo as an Animal Model for the Treatment of Hyperpigmentation in Cosmetic Dermatology Medicine.Medicina (Kaunas, Lithuania) · 2018Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background
methodsChemical structures of FGA, GRD, and GRE were determined based on spectroscopic methods, including fast atom bombardment mass spectroscopy, ID-nuclear magnetic resonance, and infrared spectroscopy. Inhibitory activities of these compounds on melanogenesis were studied by measuring the expression of protein and melanin content in the melan-a cell line. This inhibitory activity was confirmed by observing pigmentation and tyrosinase activities of zebrafish.
resultsGRD, GRE, and FGA were not cytotoxic at concentrations less than 20μM, 80μM, and 160μM in melan-a cells, respectively. GRD, GRE, and FGA inhibited melanin biosynthesis in melan-a cells by 15.2%, 22.9%, and 23.9% at 20μM, 80μM, and 160μM, respectively. FGA was observed to display the most potent inhibitory effect. In addition, FGA decreased microphthalmia-associated transcription factor protein expression in a dose-dependent manner. Moreover, FGA induced extracellular signal-regulated kinase phosphorylation level in melan-a cells. In addition, melanin pigment content and tyrosinase activity in zebrafish treated with FGA at160μM were reduced.
conclusionFGA showed the most potent inhibition of melanogenesis in both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.