Evidence map›Paper›PMID 29021638›Full record

ArticleColombia medica (Cali, Colombia)2017

Real-time PCR assay for the diagnosis of pleural tuberculosis.

Martha Alejandra Casallas-Rivera, Ana María Cárdenas Bernal, Luis Fernando Giraldo-Cadavid, Enrique Prieto Diago, Sandra Paola Santander

Open access · greenAbstract readComparative StudyValidation Study
PubMed Full text at PMC
In one paragraph

Article in Colombia medica (Cali, Colombia), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Martha Alejandra Casallas-RiveraUniversidad de la Sabana. Chía, Colombia.
Ana María Cárdenas BernalUniversidad de la Sabana. Chía, Colombia.
Luis Fernando Giraldo-CadavidUniversidad de la Sabana. Chía, Colombia.
Enrique Prieto DiagoInternal Medicine, Hospital Universitario de la Samaritana. Bogotá, Colombia.
Sandra Paola SantanderInternal Medicine, Hospital Universitario de la Samaritana. Bogotá, Colombia.
Universidad de La Sabana · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe diagnosis of pleural tuberculosis requires an invasive and time-consuming reference method. Polymerase chain reaction (PCR) is rapid, but validation in pleural tuberculosis is still weak.

objectiveTo establish the operating characteristics of real-time polymerase chain reaction (RT-PCR) hybridization probes for the diagnosis of pleural tuberculosis.

methodsThe validity of the RT-PCR hybridization probes was evaluated compared to a composite reference method by a cross-sectional study at the Hospital Universitario de la Samaritana. 40 adults with lymphocytic pleural effusion were included. Pleural tuberculosis was confirmed (in 9 patients) if the patient had at least one of three tests using the positive reference method: Ziehl-Neelsen or

resultsThe RT-PCR hybridization probes showed a sensitivity of 66.7% (95% CI: 33.2%-90.7%) and a specificity of 93.5% (95% CI: 80.3%-98.9%). The PPV was 75.0% (95% CI: 38.8%-95.6%) and a NPV of 90.6% (95% CI: 76.6%-97.6%). Two false positives were found for the test, one with pleural mesothelioma and the other with chronic pleuritis with mesothelial hyperplasia.

conclusionsThe RT-PCR hybridization probes had good specificity and acceptable sensitivity, but a negative value cannot rule out pleural tuberculosis.

Indexed as

AdultColombiaCross-Sectional StudiesFemaleHospitals, UniversityHumansMaleMesotheliomaMiddle AgedMycobacterium tuberculosisPleural EffusionPleurisyPredictive Value of TestsReal-Time Polymerase Chain ReactionSensitivity and SpecificityTuberculosis, PleuralDiagnostic testslikelihood ratiosMycobacterium tuberculosispleural effusionReal-Time Polymerase Chain Reactiontuberculosis pleuralvalidation studiesZiehl-Neelsen

Identifiers

PMID29021638
PMCPMC5625560
OpenAlexW2736102770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.