Evidence map›Paper›PMID 29021631›Full record

ArticleScientific reports2017

Deficiency of peroxiredoxin 6 or inhibition of its phospholipase A

Adel R Moawad, Maria C Fernandez, Eleonora Scarlata, Chandra Dodia, Sheldon I Feinstein, Aron B Fisher, Cristian O'Flaherty

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 46 citations in OpenAlex.

  1. Phospholipases: Where Do We Stand?Methods in molecular biology (Clifton, N.J.) · 2027
    Review
  2. Article
  3. Article
  4. Can the Quality of Semen Affect the Fertilisation Indices of Turkey Eggs?International journal of molecular sciences · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Peroxiredoxin 6 Peroxidase and CaAntioxidants (Basel, Switzerland) · 2022
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Updating Phospholipase ABiomolecules · 2020
    Review
  17. Article
  18. Reactive Oxygen Species and Male Fertility.Antioxidants (Basel, Switzerland) · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Adel R MoawadThe Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada.ORCID 0000-0003-4397-9688
Maria C FernandezThe Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada.
Eleonora ScarlataThe Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada.
Chandra DodiaInstitute for Environmental Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sheldon I FeinsteinInstitute for Environmental Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Aron B FisherInstitute for Environmental Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cristian O'FlahertyThe Research Institute of the McGill University Health Centre, McGill University, Montréal, Québec, Canada. cristian.oflaherty@mcgill.ca.
University of Pennsylvania · USMcGill University Health Centre · CACairo University · EGMcGill University · CA

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
Role of Peroxiredoxin 6 in the Repair of Peroxidized Cell MembranesR01HL102016 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FISHER, ARON B. · 2010 to 2018
$4.6M
NHLBI NIH HHS R01 HL102016NIEHS NIH HHS P30 ES013508
6 · The paper itself

Abstract

Prdx6

Indexed as

Fertilization in VitroAcrosome ReactionAnimalsCalciumEmbryonic DevelopmentFemaleGlycerophosphatesHumansLipid PeroxidationMaleMice, Inbred C57BLMitochondriaPeroxiredoxin VIPhospholipase A2 InhibitorsPhospholipases A2Spermatogenesis1-hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanolCalciumGlycerophosphatesPeroxiredoxin VIPhospholipase A2 InhibitorsPhospholipases A2Superoxides

Identifiers

PMID29021631
PMCPMC5636886
OpenAlexW2763016839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.