ArticleScientific reports2017
Perceived stress level and risk of cancer incidence in a Japanese population: the Japan Public Health Center (JPHC)-based Prospective Study.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Psychosocial factors and the risk of cancer: An individual-participant data meta-analysis.Cancer · 2026Pooled it
- Psychological Stress and Cellular Aging in Cancer: A Meta-Analysis.Oxidative medicine and cellular longevity · 2019Pooled it
- The crosstalk between nerves and immunity: chronic stress as a driver of tumor progression.Frontiers in immunology · 2026Review
- Sick Leave due to Stress and Subsequent Cancer Risk, a Swedish National Registry Study of 516,678 Cancer Cases.Cancer medicine · 2025Article
- Inequities in the Impacts of Hurricanes and Other Extreme Weather Events for Cancer Survivors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Review
- Chronic Stress Related to Cancer Incidence, including the Role of Metabolic Syndrome Components.Cancers · 2024Article
- Factors influencing the intention for lung cancer screening in high-risk populations for lung cancer.Asia-Pacific journal of oncology nursing · 2024Article
- Association between Perceived Stress and Motoric Cognitive Risk Syndrome in an Elderly Population: Rugao Longevity and Aging Study.Dementia and geriatric cognitive disorders · 2024Article
- Review
- Psychological Stress Is Associated with Increased Cancer Risk in Dogs.Animals : an open access journal from MDPI · 2023Article
- Mechanism of chronic stress to promote tumor development and the intervention.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Impacts of psychological stress on high dose-rate radiation acute effects in a mouse experimental model.Journal of radiation research · 2022Article
- Perceived stress in different countries at the beginning of the coronavirus pandemic.International journal of psychiatry in medicine · 2022Article
- Article
- Hepatitis B Virus-Associated Hepatocellular Carcinoma and Chronic Stress.International journal of molecular sciences · 2022Review
- Work-Related Stress Was Not Associated with Increased Cancer Risk in a Population-Based Cohort Setting.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Article
- An Enriched Environment Alters DNA Repair and Inflammatory Responses After Radiation Exposure.Frontiers in immunology · 2021Article
- Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer.Frontiers in cellular and infection microbiology · 2021Review
- Hepatitis B-related hepatocellular carcinoma and stress: untangling the host immune response from clinical outcomes.Hepatic oncology · 2020Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence regarding stress as a risk factor for cancer onset is inconsistent. In this study, based on the Japan Public Health Center-based Prospective Study, we enrolled 101,708 participants aged 40-69 years from 1990-1994. The self-reported perceived stress level was collected at baseline and updated through 5-year follow-up. The association between perceived stress and cancer risk was measured by Cox proportional hazards regression model, adjusted for all known confounders. During follow-up (mean = 17.8 years), we identified 17,161 cancer cases. We found no association between baseline perceived stress level and cancer incidence. However, by taking account of the dynamic changes in perceived stress, time-varying analyses revealed a slightly (4-6%) increased overall cancer risk for subjects under elevated perceived stress levels compared to the 'low stress level' group. Analyses concerning long-term perceived stress level showed that individuals with constantly high perceived stress level had an 11% (95% confidence interval 1-22%) excess risk for cancer compared to subjects with persistently low stress levels. This association was confined to men (20% excess risk), and was particularly strong among smokers, alcohol drinkers, obese subjects, and subjects without family history of cancer. Therefore, we concluded high perceived stress level might contribute to excess overall cancer incidence among men.
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