Evidence map›Paper›PMID 29021554›Full record

ArticleScientific reports2017

Human TAU

Mehmet I Cosacak, Prabesh Bhattarai, Ledio Bocova, Tim Dzewas, Violeta Mashkaryan, Christos Papadimitriou, Kerstin Brandt, Heike Hollak, Christopher L Antos, Caghan Kizil

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Zebrafish as a model organism for neurodegenerative disease.Frontiers in molecular neuroscience · 2022
    Review
  14. Review
  15. Non-Rodent Genetic Animal Models for Studying Tauopathy: Review ofInternational journal of molecular sciences · 2021
    Review
  16. Article
  17. Zebrafish Models to Study New Pathways in Tauopathies.International journal of molecular sciences · 2021
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mehmet I CosacakGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany.ORCID 0000-0003-2978-3902
Prabesh BhattaraiGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany.
Ledio BocovaGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany.
Tim DzewasGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany.
Violeta MashkaryanGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany.
Christos PapadimitriouGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany.
Kerstin BrandtGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany.
Heike HollakGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany.
Christopher L AntosSchool of Life Sciences and Technology, ShanghaiTech University, 100 Haike Road, Shanghai, China.
Caghan KizilGerman Center for Neurodegenerative Diseases (DZNE), Arnoldstrasse 18, 01307, Dresden, Germany. caghan.kizil@dzne.de.ORCID 0000-0002-8164-9762
German Center for Neurodegenerative Diseases · DEShanghaiTech University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microtubule-associated TAU protein is a pathological hallmark in Alzheimer's disease (AD), where hyperphosphorylation of TAU generates neurofibrillary tangles. To investigate the effects of TAU in a regenerative adult vertebrate brain system, we generated a cre/lox-based transgenic model of zebrafish that chronically expresses human TAU

Indexed as

AgingAmyloid beta-PeptidesAnimalsAnimals, Genetically ModifiedBehavior, AnimalBrainCell DeathHumansInflammationLarvaModels, BiologicalMutant ProteinsNerve RegenerationNeurofibrillary TanglesNeuronsPhenotypeAmyloid beta-PeptidesMutant ProteinsProliferating Cell Nuclear Antigentau Proteins

Identifiers

PMID29021554
PMCPMC5636889
OpenAlexW2762690527

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.