ArticleScientific reports2017
Functional maturation in preterm infants measured by serial recording of cortical activity.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transient Hypothyroxinemia of Prematurity: Electrophysiological Changes in the Preterm Infants' Brain, a Retrospective Study
The Role of Electroencephalography Evaluation in Caffeine Discontinuation Timing in Premature Infants
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Quantitative assessment of neurodevelopmental maturation: a comprehensive systematic literature review of artificial intelligence-based brain age prediction in pediatric populations.Frontiers in neuroinformatics · 2024Pooled it
- Applying a data-driven approach to quantify EEG maturational deviations in preterms with normal and abnormal neurodevelopmental outcomes.Scientific reports · 2020Trial
- Pain, Opioids, and Functional Connectivity in Preterm Infants.Children (Basel, Switzerland) · 2026Article
- [Research progress in electroencephalogram-based brain age prediction].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- EEG Maturational Age Estimation: A Comparison of Visual and Automated Interpretation of the EEG in Preterm Infants.Journal of clinical medicine · 2025Article
- Optimal channel and feature selection for automatic prediction of functional brain age of preterm infant based on EEG.Frontiers in neuroscience · 2025Article
- Resting state electroencephalographic brain activity in neonates can predict age and is indicative of neurodevelopmental outcome.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Human neuronal maturation comes of age: cellular mechanisms and species differences.Nature reviews. Neuroscience · 2024Review
- Sensory event-related potential morphology predicts age in premature infants.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- [A preliminary study on a new method for evaluating brain maturation in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Examining time-frequency mechanisms of full-fledged deep sleep development in newborns of different gestational age in the first days of their postnatal development.Scientific reports · 2022Article
- Relationship Between Early Functional and Structural Brain Developments and Brain Injury in Preterm Infants.Cerebellum (London, England) · 2021Article
- Development and validation of Auto-Neo-electroencephalography (EEG) to estimate brain age and predict report conclusion for electroencephalography monitoring data in neonatal intensive care units.Annals of translational medicine · 2021Article
- Reliability and accuracy of EEG interpretation for estimating age in preterm infants.Annals of clinical and translational neurology · 2020Article
- Automated cot-side tracking of functional brain age in preterm infants.Annals of clinical and translational neurology · 2020Article
- Neurocritical care of premature infants.Biomedical journal · 2020Review
- Measuring Cot-Side the Effects of Parenteral Nutrition on Preterm Cortical Function.Frontiers in human neuroscience · 2020Article
- Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.Cell stem cell · 2019Article
- Temporal evolution of quantitative EEG within 3 days of birth in early preterm infants.Scientific reports · 2019Article
- A dataset of neonatal EEG recordings with seizure annotations.Scientific data · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minimally invasive, automated cot-side tools for monitoring early neurological development can be used to guide individual treatment and benchmark novel interventional studies. We develop an automated estimate of the EEG maturational age (EMA) for application to serial recordings in preterm infants. The EMA estimate was based on a combination of 23 computational features estimated from both the full EEG recording and a period of low EEG activity (46 features in total). The combination function (support vector regression) was trained using 101 serial EEG recordings from 39 preterm infants with a gestational age less than 28 weeks and normal neurodevelopmental outcome at 12 months of age. EEG recordings were performed from 24 to 38 weeks post-menstrual age (PMA). The correlation between the EMA and the clinically determined PMA at the time of EEG recording was 0.936 (95%CI: 0.932-0.976; n = 39). All infants had an increase in EMA between the first and last EEG recording and 57/62 (92%) of repeated measures within an infant had an increasing EMA with PMA of EEG recording. The EMA is a surrogate measure of age that can accurately determine brain maturation in preterm infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.