ArticleScientific reports2017
Correlation of X-ray diffraction signatures of breast tissue and their histopathological classification.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Amentoflavone: A safe and novel penetration enhancer for transdermal applications.Chinese herbal medicines · 2026Article
- RS, S (+) - and R (-)-ibuprofen cocrystal polymorphs: Vibrational spectra, XRD measurement and DFT calculation studies.Heliyon · 2025Article
- Open-Source Data Analysis Tool for Spectral Small-Angle X-ray Scattering Using Spectroscopic Photon-Counting Detector.Sensors (Basel, Switzerland) · 2024Article
- Vitacrystallography: Structural Biomarkers of Breast Cancer Obtained by X-ray Scattering.Cancers · 2024Article
- Canine Cancer Diagnostics by X-ray Diffraction of Claws.Cancers · 2024Article
- X-ray fan beam coded aperture transmission and diffraction imaging for fast material analysis.Scientific reports · 2021Article
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Authors and funding
9 authors.
Funding
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Abstract
This pilot study examines the correlation of X-ray diffraction (XRD) measurements with the histopathological analysis of breast tissue. Eight breast cancer samples were investigated. Each sample contained a mixture of normal and cancerous tissues. In total, 522 separate XRD measurements were made at different locations across the samples (8 in total). The resulting XRD spectra were subjected to principal component analysis (PCA) in order to determine if there were any distinguishing features that could be used to identify different tissue components. 99.0% of the variation between the spectra were described by the first two principal components (PC). Comparing the location of points in PC space with the classification determined by histopathology indicated correlation between the shape/magnitude of the XRD spectra and the tissue type. These results are encouraging and suggest that XRD could be used for the intraoperative or postoperative classification of bulk tissue samples.
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