Evidence map›Paper›PMID 29021436›Full record

ArticleInternal medicine (Tokyo, Japan)2017

Multiple Myeloma Presenting with Autoimmune Autonomic Ganglionopathy.

Yoshiki Nakae, Mizuki Hyuga, Yuta Terada, Wataru Kishimoto, Akiko Fukunaga, Sumie Tabata, Yoshitomo Maesako, Kenichi Komatsu, Osamu Higuchi, Toshinari Nakane and 1 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A case of seropositive autoimmune autonomic ganglionopathy treated with rituximab: Case report and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  2. Article
  3. Autoimmune autonomic ganglionopathy associated with monoclonal gammopathy of undetermined significance: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yoshiki NakaeDepartment of Hematology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Mizuki HyugaDepartment of Hematology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Yuta TeradaDepartment of Neurology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Wataru KishimotoDepartment of Hematology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Akiko FukunagaDepartment of Hematology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Sumie TabataDepartment of Hematology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Yoshitomo MaesakoDepartment of Hematology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Kenichi KomatsuDepartment of Neurology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.
Osamu HiguchiDepartment of Clinical Research, National Hospital Organization Nagasaki Kawatana Medical Center, Japan.
Toshinari NakaneDepartment of Neurology, Kumamoto University, Japan.
Nobuyoshi ArimaDepartment of Hematology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune autonomic ganglionopathy is an autonomic disorder that occurs as a symptom of paraneoplastic neurological syndrome. To date, there have been no reports on multiple myeloma with autoimmune autonomic ganglionopathy. A 37-year-old Japanese woman suffered from orthostatic hypotension was diagnosed with multiple myeloma (IgG kappa type), and a serological examination revealed the presence of anti-ganglionic nicotinic acetylcholine receptor (anti-gAChR) antibodies. She was treated for multiple myeloma, as a result, the autonomic disturbance improved and her anti-gAChR antibody titer decreased to undetectable levels, despite the fact that she only achieved a partial remission of multiple myeloma. Treatment for multiple myeloma may improve autoimmune autonomic ganglionopathy.

Indexed as

AdultAutoantibodiesAutonomic Nervous System DiseasesFemaleGanglia, AutonomicHumansMultiple MyelomaReceptors, NicotinicAutoantibodiesReceptors, Nicotinicautoimmune autonomic ganglionopathyautonomic disturbancemultiple myeloma

Identifiers

PMID29021436
PMCPMC5790725

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.