Evidence map›Paper›PMID 29021405›Full record

ArticleSexually transmitted infections2018

High prevalence of high-risk HPV genotypes other than 16 and 18 in cervical cancers of Curaçao: implications for choice of prophylactic HPV vaccine.

Desiree J Hooi, Birgit I Lissenberg-Witte, Maurits N C de Koning, Herbert M Pinedo, Gemma G Kenter, Chris Jlm Meijer, Wim G Quint

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sexually transmitted infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Frequency ofIranian journal of pathology · 2024
    Article
  3. Article
  4. Review
  5. Article
  6. Prevalence of Human Papillomavirus Genotypes in Tehran, Iran.Journal of research in health sciences · 2022
    Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Desiree J HooiFundashon Prevenshon, Willemstad, Curaçao.
Birgit I Lissenberg-WitteDepartment of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, the Netherlands.
Maurits N C de KoningDDL Diagnostic Laboratory, Rijswijk, the Netherlands.
Herbert M PinedoFundashon Prevenshon, Willemstad, Curaçao.
Gemma G KenterDepartment of Gynaecology and Oncology, VU University Medical Centre, Amsterdam, the Netherlands.
Chris Jlm MeijerDepartment of Pathology, VU University Medical Centre, Amsterdam, the Netherlands.
Wim G QuintDDL Diagnostic Laboratory, Rijswijk, the Netherlands.
Amsterdam UMC Location VUmc · NLDDL Diagnostic Laboratory · NLUniversity of Curaçao · CW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCuraçao is a Dutch-Caribbean Island located in a high-risk area for cervical cancer.Prior to introduction of a prophylactic human papillomavirus (HPV) vaccine, knowledge of the prevalence of high-risk HPV vaccine genotypes (HPV16, 18, 31, 33, 45, 52 and 58) in cervical (pre)cancer is required.

objectiveTo investigate the prevalence of HPV genotypes in invasive cervical cancers (ICC) and cervical intraepithelial neoplasia (CIN) grade 1, 2 and 3 in Curaçao.

methodsParaffin-embedded blocks of 104 cervical cancers (89 squamous, 15 adenocarcinoma), 41 CIN3, 39 CIN2 and 40 CIN1 lesions were analysed for the presence of HPV. Sections were stained by H&E for histopathological evaluation, and DNA was extracted using proteinase K. HPV genotypes were detected using Short PCR Fragment (SPF10) PCR DNA enzyme immunoassay and a Line Probe Assay (LiPA25) .

resultsHPV was found in 92 (88.5%) ICC; 87 (94.6%) had a single HPV infection and 86 (93.5%) were high-risk human papillomavirus (hrHPV)-type positive.The three most common HPV types in ICC were 16 (38.5%), 18 (13.5%) and 45 (6.7%), covering 58.7%.HrHPV vaccine genotypes 16, 18, 31, 35, 45, 52 and 58 were responsible for 73.1% of ICC. For precancerous lesions, the HPV attribution was 85.4% for CIN3, 66.7% for CIN2% and 42.5% for CIN1.

conclusionsOur study, the largest in the Caribbean region in (pre)cancer, shows that the prevalence of HPV-type 16 and 18 in cervical cancer is lower compared with the world population but no differences in prevalence of these two HPV types are seen in precancerous lesions.When considering HPV vaccination in Curaçao, the relatively high contribution of non-HPV 16/18 genotypes in ICC should be taken into account.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overAlphapapillomavirusCarcinoma, Squamous CellCuracaoEarly Detection of CancerFemaleGenotypeHumansMass ScreeningMiddle AgedPapillomavirus InfectionsPapillomavirus VaccinesPrevalencePapillomavirus VaccinesCervical cancerCervical intraepithelial neoplasia(CIN)CuraçaoHPV genotypesHPV prevalenceHPV vaccination

Identifiers

PMID29021405
PMCPMC5969325
OpenAlexW2762374148

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.