Evidence map›Paper›PMID 29021396›Full record

ArticleJournal of virology2017

Quiescence Promotes Latent HIV Infection and Resistance to Reactivation from Latency with Histone Deacetylase Inhibitors.

Mark M Painter, Thomas D Zaikos, Kathleen L Collins

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Natural Resistance to HIV Infection: Role of Immune Activation.Immunity, inflammation and disease · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Hematopoietic Stem and Progenitor Cells (HSPCs).Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mark M PainterGraduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Thomas D ZaikosDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Kathleen L CollinsGraduate Program in Immunology, University of Michigan, Ann Arbor, Michigan, USA klcollin@umich.edu.
University of Michigan–Ann Arbor · US

Funding

RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
HIV Infection of Hematopoietic Progenitor CellsR01AI096962 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 2012 to 2016
$2.9M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI096962NIAID NIH HHS T32 AI007413
6 · The paper itself

Abstract

Human immunodeficiency virus type 1 (HIV-1) establishes transcriptionally silent latent infections in resting memory T cells and hematopoietic stem and progenitor cells (HSPCs), which allows the virus to persist in infected individuals despite antiretroviral therapy. Developing

Indexed as

Resting Phase, Cell CycleCD4-Positive T-LymphocytesCell ProliferationCells, CulturedCryobiologyFetal BloodGene Expression Regulation, ViralHematopoietic Stem CellsHistone Deacetylase InhibitorsHIV-1HSP90 Heat-Shock ProteinsHumansNF-kappaB-Inducing KinaseProtein Serine-Threonine KinasesVirus ActivationVirus LatencyHistone Deacetylase InhibitorsHSP90 Heat-Shock ProteinsNF-kappaB-Inducing KinaseProtein Serine-Threonine Kinases17-AAGbryostatinhistone deacetylase inhibitorsHIVHSP90latencyNF-κBP-TEFbquiescencestem cells

Identifiers

PMID29021396
PMCPMC5709582
OpenAlexW2763232018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.