Evidence map›Paper›PMID 29021385›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Aldosterone Is Essential for Angiotensin II-Induced Upregulation of Pendrin.

Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Atsushi Watanabe, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Integrated morphological and transcriptomic analysis of bone disorders in aldosterone-salt hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  3. Review
  4. Review
  5. Novel functions of the anion exchanger AE4 (SLC4A9).Pflugers Archiv : European journal of physiology · 2024
    Review
  6. Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.American journal of physiology. Renal physiology · 2024
    Article
  7. Review
  8. Review
  9. Review
  10. Pendrin regulation is prioritized by anion in high-potassium diets.American journal of physiology. Renal physiology · 2023
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Role of Rho in Salt-Sensitive Hypertension.International journal of molecular sciences · 2021
    Review
  17. Review
  18. PGIInternational journal of molecular sciences · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Daigoro HirohamaDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan; Toshiro.FUJITA@rcast.u-tokyo.ac.jp hirohama-tky@umin.ac.jp.
Nobuhiro AyuzawaDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Kohei UedaDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Mitsuhiro NishimotoDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Wakako KawarazakiDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Atsushi WatanabeDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Tatsuo ShimosawaDepartment of Clinical Laboratory, School of Medicine, International University of Health and Welfare, Chiba, Japan.
Takeshi MarumoDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Shigeru ShibataDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Toshiro FujitaDivision of Clinical Epigenetics, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan; Toshiro.FUJITA@rcast.u-tokyo.ac.jp hirohama-tky@umin.ac.jp.
The University of Tokyo · JPInternational University of Health and Welfare · JPJapan Science and Technology Agency · JPTeikyo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The renin-angiotensin-aldosterone system has an important role in the control of fluid homeostasis and BP during volume depletion. Dietary salt restriction elevates circulating angiotensin II (AngII) and aldosterone levels, increasing levels of the Cl

Indexed as

AdrenalectomyAldosteroneAngiotensin IIAnimalsBlood PressureKidney Tubules, DistalMaleMice, Inbred C57BLMice, KnockoutPhosphorylationReceptors, MineralocorticoidSodium Chloride, DietarySodium Chloride SymportersSulfate TransportersUp-RegulationVasoconstrictor AgentsAldosteroneAngiotensin IIReceptors, MineralocorticoidSlc26a4 protein, mouseSodium Chloride, DietarySodium Chloride SymportersSulfate TransportersVasoconstrictor AgentsaldosteroneangiotensinNa transport

Identifiers

PMID29021385
PMCPMC5748905
OpenAlexW2763999097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.