Evidence map›Paper›PMID 29021323›Full record

ArticleCirculation2017

Pathologic Stimulus Determines Lineage Commitment of Cardiac C-kit

Zhongming Chen, Wuqiang Zhu, Ingrid Bender, Wuming Gong, Il-Youp Kwak, Amritha Yellamilli, Thomas J Hodges, Natsumi Nemoto, Jianyi Zhang, Daniel J Garry and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. International journal of molecular sciences · 2021
    Review
  5. Review
  6. Article
  7. Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Role of c-Kit in Myocardial Regeneration and Aging.Frontiers in endocrinology · 2019
    Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zhongming ChenDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Wuqiang ZhuDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Ingrid BenderDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Wuming GongDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Il-Youp KwakDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Amritha YellamilliLillehei Heart Institute, University of Minnesota, Minneapolis (Z.C., I.B., W.G., I-Y.K., A.Y., N.N., D.J.G., J.H.v.B.).
Thomas J HodgesDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Natsumi NemotoDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Jianyi ZhangDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Daniel J GarryDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.).
Jop H van BerloDepartment of Medicine, Cardiovascular Division, University of Minnesota, Minneapolis (Z.C., W.Z., I.B., W.G., I-Y.K., T.J.H., N.N., J.Z., D.J.G., J.H.v.B.) jvanberl@umn.edu.
University of Minnesota · USMinneapolis Heart Institute Foundation · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
Endogenous and exogenous mechanisms that promote myocardial remuscularization in post infarction LV remodelingR01HL114120 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2012 to 2021
$5.6M
Stem Cells For Myocardial Repair: A Large Bore Magnet StudyR01HL095077 · NHLBI · UNIVERSITY OF MINNESOTA · PI ZHANG, JIANYI · 2009 to 2017
$3.8M
Strategic activation of endogenous c-kit+ progenitor cells for cardiac regenerationR01HL130072 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2016 to 2020
$1.9M
Regulatory Mechanisms of Endothelial Development and RegenerationR01HL122576 · NHLBI · UNIVERSITY OF MINNESOTA · PI GARRY, DANIEL J. · 2014 to 2017
$1.5M
Functional relevance of cardiac regeneration by c-kit positive stem cellsR00HL112852 · NHLBI · UNIVERSITY OF MINNESOTA · PI VAN BERLO, JOHANNES (JOP) · 2013 to 2015
$712k
Functional relevance of cardiac regeneration by c-kit positive stem cellsK99HL112852 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI VAN BERLO, JOHANNES (JOP) · 2012 to 2013
$263k
NHLBI NIH HHS K99 HL112852NHLBI NIH HHS R00 HL112852NHLBI NIH HHS R01 HL095077NHLBI NIH HHS R01 HL114120NHLBI NIH HHS R01 HL122576NHLBI NIH HHS R01 HL130072NIGMS NIH HHS T32 GM008244
6 · The paper itself

Abstract

backgroundAlthough cardiac c-kit

methodsWe used single-cell sequencing and genetic lineage tracing of c-kit

resultsSingle-cell sequencing of cardiac CD45

conclusionsThese results demonstrate that different pathological stimuli induce different cell fates of c-kit

Indexed as

AnimalsCell DifferentiationCell LineageCells, CulturedDoxorubicinEndothelial CellsMesenchymal Stem CellsMiceMice, Inbred C57BLMice, Inbred CBAMice, KnockoutMyocardiumMyocytes, CardiacProto-Oncogene Proteins c-kitSequence Analysis, DNASingle-Cell AnalysisDoxorubicinProto-Oncogene Proteins c-kitTumor Suppressor Protein p53adult stem cellsanthracyclinesc-kitheart failureregeneration

Identifiers

PMID29021323
PMCPMC5726921
OpenAlexW2762377596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.