Evidence map›Paper›PMID 29021322›Full record

Trial reportCirculation2018

Influence of Baseline Diastolic Blood Pressure on Effects of Intensive Compared With Standard Blood Pressure Control.

Srinivasan Beddhu, Glenn M Chertow, Alfred K Cheung, William C Cushman, Mahboob Rahman, Tom Greene, Guo Wei, Ruth C Campbell, Margaret Conroy, Barry I Freedman and 12 more

Registry-linked trialAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01206062 (Systolic Blood Pressure Intervention Trial), which is not on this map. Cited by 81 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01206062 nacompletednot on this map

Systolic Blood Pressure Intervention Trial

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2010 to 2019Enrolled9,361ConditionsHypertensionArmsIntensive control of SBP, Standard control of SBP
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Guideline
  4. Hypertension Canada guideline for the diagnosis and treatment of hypertension in adults in primary care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Guideline
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Trial
  9. Trial
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  18. Article
  19. Blood Pressure Control and Mortality Among US Veterans.Hypertension (Dallas, Tex. : 1979) · 2026
    Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Srinivasan BeddhuMedical Service, Veterans Affairs Salt Lake City Health Care System, UT (S.B., A.K.C.) srinivasan.beddhu@hsc.utah.edu.
Glenn M ChertowUniversity of Utah School of Medicine, Salt Lake City. Stanford University, Palo Alto, CA (G.M.C.).
Alfred K CheungMedical Service, Veterans Affairs Salt Lake City Health Care System, UT (S.B., A.K.C.).
William C CushmanVeterans Affairs Medical Center, Memphis, TN (W.C.C.).
Mahboob RahmanCase Western Reserve University, Cleveland, OH (M.R., E.H.).
Tom GreeneDivision of Biostatistics (T.G.).
Guo WeiDivision of Nephrology and Hypertension (S.B., A.K.C., G.W.).
Ruth C CampbellMedical University of South Carolina, Charleston (R.C.C., R.P.).
Margaret ConroyDivision of General Internal Medicine (M.C.).
Barry I FreedmanSection on Nephrology (B.I.F.).
William HaleyWake Forest School of Medicine, Winston-Salem, NC. Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL (W.H.).
Edward HorwitzCase Western Reserve University, Cleveland, OH (M.R., E.H.).
Dalane KitzmanSection on Cardiology (D.K.).
James LashUniversity of Illinois at Chicago, IL (J.L.).
Vasilios PapademetriouDivision of Cardiology, Veterans Administration Medical Center, Washington, DC (V.P.).
Roberto PisoniMedical University of South Carolina, Charleston (R.C.C., R.P.).
Erik RiessenIntermountain Medical Center, Murray, UT (E.R.).
Clive RosendorffIcahn School of Medicine at Mount Sinai, New York, NY (C.R.).
Suzanne G WatnickOregon State Health University Portland (S.G.W.).
Jeffrey WhittlePrimary Care Division, Clement J. Zablocki VA Medical Center, Milwaukee, WI (J.W.).
Paul K WheltonTulane University School of Public Health and Tropical Medicine, New Orleans, LA (P.K.W.).
SPRINT Research Group

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Institutional Clinical and Translational Science AwardUL1TR000003 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2012 to 2015
$38.9M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Tufts Clinical and Translational Research InstituteUL1TR001064 · NCATS · TUFTS UNIVERSITY BOSTON · PI SELKER, HARRY P. · 2013 to 2017
$26.4M
University of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3M
UNIVERSITY OF UTAH CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE-UL1: BPCAUL1RR025764 · NCRR · UNIVERSITY OF UTAH · PI MCCLAIN, DONALD A. · 2008 to 2011
$19.4M
NCATS NIH HHS UL1 TR000002NCATS NIH HHS UL1 TR000003NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000073NCATS NIH HHS UL1 TR000075NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000105NCATS NIH HHS UL1 TR000433NCATS NIH HHS UL1 TR000439NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR001064NCATS NIH HHS UL1 TR001427NCATS NIH HHS UL1 TR002003NCATS NIH HHS UL1 TR002240NCRR NIH HHS C06 RR011234NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR025752NCRR NIH HHS UL1 RR025755NCRR NIH HHS UL1 RR025764NCRR NIH HHS UL1 RR025771NHLBI NIH HHS HHSN268200900040CNHLBI NIH HHS HHSN268200900046CNHLBI NIH HHS HHSN268200900047CNHLBI NIH HHS HHSN268200900048CNHLBI NIH HHS HHSN268200900049CNIDDK NIH HHS R01 DK091437NIDDK NIH HHS R21 DK106574NIGMS NIH HHS P30 GM103337
6 · The paper itself

Abstract

backgroundIn individuals with a low diastolic blood pressure (DBP), the potential benefits or risks of intensive systolic blood pressure (SBP) lowering are unclear.

methodsSPRINT (Systolic Blood Pressure Intervention Trial) was a randomized controlled trial that compared the effects of intensive (target <120 mm Hg) and standard (target <140 mm Hg) SBP control in 9361 older adults with high blood pressure at increased risk of cardiovascular disease. The primary outcome was a composite of cardiovascular disease events. All-cause death and incident chronic kidney disease were secondary outcomes. This post hoc analysis examined whether the effects of the SBP intervention differed by baseline DBP.

resultsMean baseline SBP and DBP were 139.7±15.6 and 78.1±11.9 mm Hg, respectively. Regardless of the randomized treatment, baseline DBP had a U-shaped association with the hazard of the primary cardiovascular disease outcome. However, the effects of the intensive SBP intervention on the primary outcome were not influenced by baseline DBP level (

conclusionsLow baseline DBP was associated with increased risk of cardiovascular disease events, but there was no evidence that the benefit of the intensive SBP lowering differed by baseline DBP. CLINICAL

trial registrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01206062.

Indexed as

Acute Coronary SyndromeAgedAged, 80 and overAntihypertensive AgentsBlood PressureDiastoleFemaleHumansHypertensionIncidenceMaleMiddle AgedMyocardial InfarctionPuerto RicoRenal Insufficiency, ChronicRisk FactorsAntihypertensive Agentsblood pressurehypertensionrandomized controlled trial

Identifiers

PMID29021322
PMCPMC5760457

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.