ReviewClinical and vaccine immunology : CVI2017
Recent Approaches To Optimize Laboratory Assessment of Antinuclear Antibodies.
Review in Clinical and vaccine immunology : CVI, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cell-based ELISA using intact HEp-2 cells: an alternative approach for antinuclear antibody detection.Immunologic research · 2026Article
- New Insights Into Diffuse Sclerosing Osteomyelitis: Is There a Role of ANA and Vitamin B6?Oral diseases · 2026Article
- Changes in ANA Positivity Following SARS-CoV-2 Outbreak in Lombardy Region, Italy.Journal of medical virology · 2026Article
- Comparison of artificial intelligence applications and commercial system performances using selected ANA IIF images.Immunologic research · 2025Article
- Artificial intelligence applications for immunology laboratory: image analysis and classification study of IIF photos.Immunologic research · 2024Article
- Evaluation of the Accuracy of Estimated Endpoint Titer of NOVA View in Indirect Immunofluorescent Antinuclear Antibody Testing.Diagnostics (Basel, Switzerland) · 2024Article
- The clinical significance of anti-DFS70 autoantibodies and its correlation with Vitamin D levels.Northern clinics of Istanbul · 2022Article
- Correlation Between the Presence of Antinuclear Antibodies and Recurrent Pregnancy Loss: A Mini Review.Frontiers in endocrinology · 2022Review
- Presence of anti-nuclear antibody associated with worse clinical outcomes of anti-NMDAR encephalitis.Frontiers in neurology · 2022Article
- Application of Supervised Machine Learning to Recognize Competent Level and Mixed Antinuclear Antibody Patterns Based on ICAP International Consensus.Diagnostics (Basel, Switzerland) · 2021Article
- The antinuclear antibody HEp-2 indirect immunofluorescence assay: a survey of laboratory performance, pattern recognition and interpretation.Auto- immunity highlights · 2021Article
- Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease.Antibodies (Basel, Switzerland) · 2021Review
- Patients with Interstitial Lung Disease Secondary to Autoimmune Diseases: How to Recognize Them?Diagnostics (Basel, Switzerland) · 2020Review
- The binding of SLE autoantibodies to mitochondria.Clinical immunology (Orlando, Fla.) · 2020Article
- Evaluation of a Fully Automated Antinuclear Antibody Indirect Immunofluorescence Assay in Routine Use.Frontiers in immunology · 2020Article
- A Multicenter Analysis of Subjectivity of Indirect Immunofluorescence Test in Antinuclear Antibody Screening.Archives of rheumatology · 2019Article
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of antinuclear antibodies (ANAs) is a hallmark of a number of systemic autoimmune rheumatic diseases, and testing is usually performed as part of the initial diagnostic workup when suspicion of an underlying autoimmune disorder is high. The indirect immunofluorescence antibody (IFA) technique is the preferred method for detecting ANAs, as it demonstrates binding to specific intracellular structures within the cells, resulting in a number of staining patterns that are usually categorized based on the cellular components recognized and the degree of binding, as reflected by the fluorescence intensity or titer. As a screening tool, the ANA patterns can guide confirmatory testing useful in elucidating a specific clinical diagnosis or prognosis. However, routine use of ANA IFA testing as a global screening test is hampered by its labor-intensiveness, subjectivity, and limited diagnostic specificity, among other factors. This review focuses on current efforts to standardize the nomenclature of ANA patterns and on alternative methods for ANA determination, as well as on recent advances in image-based computer algorithms to automate IFA testing in clinical laboratories.
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Registered trials
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