Evidence map›Paper›PMID 29021275›Full record

SynthesisJournal of the American Heart Association2017

Impact of Coronary Artery Disease on 30-Day and 1-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement: A Meta-Analysis.

Kesavan Sankaramangalam, Kinjal Banerjee, Krishna Kandregula, Divyanshu Mohananey, Akhil Parashar, Brandon M Jones, Yash Jobanputra, Stephanie Mick, Amar Krishnaswamy, Lars G Svensson and 1 more

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. What Are SAVR Indications in the TAVI Era?Journal of clinical medicine · 2025
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kesavan SankaramangalamDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.
Kinjal BanerjeeDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.
Krishna KandregulaDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.
Divyanshu MohananeyDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH.
Akhil ParasharDepartment of Internal Medicine, Cleveland Clinic, Cleveland, OH.
Brandon M JonesDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.
Yash JobanputraDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.
Stephanie MickDepartment of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH.
Amar KrishnaswamyDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH.
Lars G SvenssonDepartment of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH.
Samir R KapadiaDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH kapadis@ccf.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of coronary artery disease (CAD) on outcomes after transcatheter aortic valve replacement (TAVR) is understudied. Literature on the prognostic role of CAD in the survival of patients undergoing TAVR shows conflicting results. This meta-analysis aims to investigate how CAD impacts patient survival following TAVR. METHODS AND

resultsWe completed a comprehensive literature search of Embase, MEDLINE, and the Cochrane Library, and included studies reporting outcome of TAVR based on CAD status of patients for the analysis. From the initial 1631 citations, 15 studies reporting on 8013 patients were analyzed using a random-effects model. Of the 8013 patients undergoing TAVR, with a median age of 81.3 years (79-85.1 years), 46.6% (40-55.7) were men and 3899 (48.7%) had CAD (ranging from 30.8% to 78.2% in various studies). Overall, 3121 SAPIEN/SAPIEN XT/SAPIEN 3 (39.6%) and 4763 CoreValve (60.4%) prostheses were implanted, with transfemoral access being the most frequently used approach for the implantation (76.1%). Our analysis showed no significant difference between patients with and without CAD for all-cause mortality at 30 days post TAVR, with a cumulative odds ratio of 1.07 (95% confidence interval, 0.82-1.40;

conclusionsEven though coexisting CAD does not impact 30-day mortality, it does have an impact on 1-year mortality in patients undergoing TAVR. Our results highlight a need to revisit the revascularization strategies for concomitant CAD in patients with TAVR.

Indexed as

AgedAged, 80 and overAortic Valve StenosisCause of DeathComorbidityCoronary Artery DiseaseFemaleHeart Valve ProsthesisHumansMaleOdds RatioProsthesis DesignRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment Outcomecoronary artery diseasemeta‐analysisrevascularizationtranscatheter aortic valve implantationtranscatheter aortic valve replacement

Identifiers

PMID29021275
PMCPMC5721835

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.