Evidence map›Paper›PMID 29021257›Full record

ArticleCirculation. Cardiovascular imaging2017

Presence, Characteristics, and Prognostic Associations of Carotid Plaque Among People Living With HIV.

Sumbal A Janjua, Pedro V Staziaki, Balint Szilveszter, Richard A P Takx, Thomas Mayrhofer, Orla Hennessy, Hamed A Emami, Jakob Park, Alexander Ivanov, Travis R Hallett and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
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  4. Review
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  6. Menopausal Hormone Therapy and Subclinical Cardiovascular Disease in Women With and Without Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Sumbal A JanjuaFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Pedro V StaziakiFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Balint SzilveszterFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Richard A P TakxFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Thomas MayrhoferFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Orla HennessyFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Hamed A EmamiFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Jakob ParkFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Alexander IvanovFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Travis R HallettFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Michael T LuFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Javier M RomeroFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Steven K GrinspoonFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Udo HoffmannFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Markella V ZanniFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston.
Tomas G NeilanFrom the Cardiac MR PET CT Program, Department of Radiology (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Neuroradiology Division, Department of Radiology (J.M.R.), Program in Nutritional Metabolism (S.K.G., M.V.Z.), and Division of Cardiology, Department of Medicine (S.A.J., P.V.S., B.S., R.A.P.T., T.M., O.H., H.A.E., J.P., A.I., T.R.H., M.T.L., U.H., T.G.N.), Massachusetts General Hospital and Harvard Medical School, Boston. tneilan@partners.org.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Cardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9M
STOP-CA: Statins to prevent Cardiotoxicity from AnthracyclinesR01HL130539 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G, SCHERRER-CROSBIE, MARIELLE · 2016 to 2020
$3.2M
Mechanisms of Cardiac Dysfunction in HIV and the Effect of StatinsR01HL137562 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G, ZANNI, MARKELLA V. · 2017 to 2020
$2.7M
NHLBI NIH HHS R01 HL130539NHLBI NIH HHS R01 HL137562NHLBI NIH HHS T32 HL076136NIAID NIH HHS P30 AI060354NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

backgroundData from broad populations have established associations between incidental carotid plaque and vascular events. Among people living with HIV (PLWHIV), the risk of vascular events is increased; however, whether incidental carotid plaque is increased and there is an association between incidental carotid plaque, plaque characteristics, and vascular events among PLWHIV is unclear. METHODS AND

resultsData from the multi-institutional Research Patient Data Registry were used. Presence and characteristics (high-risk plaque, including spotty calcification and low attenuation) of carotid plaque by computerized tomography among PLWHIV without known vascular disease were described. Data were compared with uninfected controls similar in age, sex, and cardiovascular risk factors, including diabetes mellitus, hyperlipidemia, and cigarette smoking to cases. Primary outcome was an atherosclerotic cardiovascular disease event, and secondary outcome was ischemic stroke. Cohort consisted of 209 PLWHIV (45±10 years, 72% male) and 168 controls. Using computerized tomography, PLWHIV without vascular disease had higher rates of any carotid plaque (34% versus 25%;

conclusionsThere is an increase in incidental carotid plaque, noncalcified plaque, and high-risk plaque among PLWHIV, and the presence and characteristics of carotid plaque are associated with subsequent vascular events.

Indexed as

Plaque, AtheroscleroticAdultBrain IschemiaCarotid ArteriesCarotid Artery DiseasesChi-Square DistributionComorbidityComputed Tomography AngiographyDisease-Free SurvivalDisease ProgressionFemaleHIV InfectionsHumansIncidenceKaplan-Meier EstimateMaleatherosclerotic cardiovascular disease eventscardiovascular diseasecarotid plaqueHIVstroke

Identifiers

PMID29021257
PMCPMC5679423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.