Evidence map›Paper›PMID 29021253›Full record

ArticleThe Journal of biological chemistry2017

Nuclear export factor 3 regulates localization of small nucleolar RNAs.

Melissa W Li, Arthur C Sletten, Jiyeon Lee, Kelly D Pyles, Scot J Matkovich, Daniel S Ory, Jean E Schaffer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Nucleolar stress: Friend or foe in cardiac function?Frontiers in cardiovascular medicine · 2022
    Review
  7. Stable lariats bearing a snoRNA (slb-snoRNA) in eukaryotic cells: A level of regulation for guide RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. The Existence and Localization of Nuclear snoRNAs inPlants (Basel, Switzerland) · 2020
    Article
  13. Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Melissa W LiDiabetes Research Center, Department of Medicine, St. Louis, Missouri 63110.
Arthur C SlettenDiabetes Research Center, Department of Medicine, St. Louis, Missouri 63110.
Jiyeon LeeDiabetes Research Center, Department of Medicine, St. Louis, Missouri 63110.
Kelly D PylesDiabetes Research Center, Department of Medicine, St. Louis, Missouri 63110.
Scot J MatkovichCenter for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110.
Daniel S OryDiabetes Research Center, Department of Medicine, St. Louis, Missouri 63110.
Jean E SchafferDiabetes Research Center, Department of Medicine, St. Louis, Missouri 63110. Electronic address: jschaff@wustl.edu.
Washington University in St. Louis · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Jennifer Lynn Powers Carson · 2013 to 2026
$27.1M
CARDIOVASCULAR SYSTEM--FUNCTION/REGULATION/PHARMACOLOGYT32HL007275 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 1985 to 2013
$6.0M
CELLULAR MECHANISMS THAT PROMOTE OR PREVENT LIPOTOXICITYR01DK064989 · NIDDK · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 2003 to 2021
$5.8M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NHLBI NIH HHS T32 HL007275NIDDK NIH HHS P30 DK020579NIDDK NIH HHS R01 DK064989
6 · The paper itself

Abstract

Small nucleolar RNAs (snoRNAs) guide chemical modifications of ribosomal and small nuclear RNAs, functions that are carried out in the nucleus. Although most snoRNAs reside in the nucleolus, a growing body of evidence indicates that snoRNAs are also present in the cytoplasm and that snoRNAs move between the nucleus and cytoplasm by a mechanism that is regulated by lipotoxic and oxidative stress. Here, in a genome-wide shRNA-based screen, we identified nuclear export factor 3 (NXF3) as a transporter that alters the nucleocytoplasmic distribution of box C/D snoRNAs from the ribosomal protein L13a (

Indexed as

Active Transport, Cell NucleusAnimalsBase SequenceCell NucleusCytoplasmMiceNucleocytoplasmic Transport ProteinsRibosomal ProteinsRNA-Binding ProteinsRNA, Small NucleolarNucleocytoplasmic Transport ProteinsNXF3 protein, mouseRibosomal ProteinsRNA-Binding ProteinsRNA, Small NucleolarRpl13a protein, mouseintracellular traffickingmolecular cell biologynuclear transportRNA transportsmall nucleolar RNA (snoRNA)

Identifiers

PMID29021253
PMCPMC5724009
OpenAlexW2761469880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.