Evidence map›Paper›PMID 29021241›Full record

ArticleGenes & development2017

Two distinct transcription termination modes dictated by promoters.

Takashi S Miki, Sarah H Carl, Helge Großhans

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Takashi S MikiFriedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.ORCID 0000-0003-3715-7039
Sarah H CarlFriedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.ORCID 0000-0003-3927-2559
Helge GroßhansFriedrich Miescher Institute for Biomedical Research, 4002 Basel, Switzerland.ORCID 0000-0002-8169-6905
Friedrich Miescher Institute · CHSIB Swiss Institute of Bioinformatics · CH

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Transcription termination determines the ends of transcriptional units and thereby ensures the integrity of the transcriptome and faithful gene regulation. Studies in yeast and human cells have identified the exoribonuclease XRN2 as a key termination factor for protein-coding genes. Here we performed a genome-wide investigation of RNA polymerase II (Pol II) transcription termination in XRN2-deficient

Indexed as

Promoter Regions, GeneticAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsExoribonucleasesRNA InterferenceRNA, MessengerRNA Polymerase IITranscription Termination, GeneticCaenorhabditis elegans ProteinsExoribonucleasesRNA, MessengerRNA Polymerase IIXRN-2 protein, C elegansRNA polymerase IItranscription terminationXRN2, Caenorhabditis elegans

Identifiers

PMID29021241
PMCPMC5695088
OpenAlexW2762992799

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.