Evidence map›Paper›PMID 29021240›Full record

ArticleGenes & development2017

Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.

Rasoul Pourebrahim, Yun Zhang, Bin Liu, Ruli Gao, Shunbin Xiong, Patrick P Lin, Mark J McArthur, Michael C Ostrowski, Guillermina Lozano

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Mutant p53 regulates reversible subtype plasticity in pancreatic cancer.Cellular and molecular life sciences : CMLS · 2025
    Article
  6. Small nucleolar RNAs: the hidden precursors of cancer ribosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  7. Pre-clinical Murine Models of Bone Sarcomas.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  8. SnoRNAs: The promising targets for anti-tumor therapy.Journal of pharmaceutical analysis · 2024
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Triple-negative breast tumors are dependent on mutant p53 for growth and survival.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Article
  17. Article
  18. Rewired mNature communications · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rasoul PourebrahimDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Yun ZhangDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Bin LiuDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Ruli GaoDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Shunbin XiongDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Patrick P LinDepartment of Orthopedic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Mark J McArthurDepartment of Veterinary Medicine and Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
Michael C OstrowskiDepartment of Cancer Biology and Genetics, The Ohio State University, Columbus, Ohio 43210, USA.
Guillermina LozanoDepartment of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
The University of Texas MD Anderson Cancer Center · USThe Ohio State University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Role of p53 Missense Mutations on Tumorigenesis in VivoR01CA082577 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LOZANO, GUILLERMINA · 1999 to 2024
$7.3M
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA082577
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsBone NeoplasmsDown-RegulationGene Expression ProfilingHumansLiver NeoplasmsLung NeoplasmsMiceMice, KnockoutMutationNeoplasm MetastasisOligonucleotide Array Sequence AnalysisOsteoblastsOsteosarcomaProto-Oncogene Protein c-ets-2Ets2 protein, mouseProto-Oncogene Protein c-ets-2RNA, Small NucleolarTumor Suppressor Protein p53Ets2metastasisosteosarcomap53snoRNA

Identifiers

PMID29021240
PMCPMC5695086
OpenAlexW2763877889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.