ArticleThe Journal of cell biology2017
An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.
Article in The Journal of cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- The endo-lysosomal system drives lumen formation in a human epiblast model.Nature communications · 2026Article
- Bulk delivery of a preassembled apical surface initiates epithelial lumen formation.Nature communications · 2026Article
- CLDN10-driven lineage decision in an amnion and primordial germ cell progenitor at the amnion-epiblast boundary in primates.Genome biology · 2025Article
- TFAP2A+ embryonic progenitor cells undergo fate diversification to give rise to human amnion, germline, and mesoderm.bioRxiv : the preprint server for biology · 2025Article
- Morphological Characterization of Intrafollicular Epithelial Bodies (IFEBs) in Rabbit Peyer's Patches.International journal of molecular sciences · 2025Article
- Primate amnion development.Development (Cambridge, England) · 2024Review
- Article
- Lumen expansion is initially driven by apical actin polymerization followed by osmotic pressure in a human epiblast model.Cell stem cell · 2024Article
- Temporally resolved early BMP-driven transcriptional cascade during human amnion specification.bioRxiv : the preprint server for biology · 2024Article
- Microfibrous Scaffolds Guide Stem Cell Lumenogenesis and Brain Organoid Engineering.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- Branched-chain actin dynamics polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains.Science advances · 2023Article
- Basal stem cell progeny establish their apical surface in a junctional niche during turnover of an adult barrier epithelium.Nature cell biology · 2023Article
- Monitoring Effects of Membrane Traffic Via Changes in Cell Polarity and Morphogenesis in Three-Dimensional Human Pluripotent Stem Cell Cysts.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Gradient tracking in mating yeast depends on Bud1 inactivation and actin-independent vesicle delivery.The Journal of cell biology · 2022Article
- Human epiblast lumenogenesis: From a cell aggregate to a lumenal cyst.Seminars in cell & developmental biology · 2022Review
- De novo apical domain formation inside theeLife · 2022Article
- Engineering multiscale structural orders for high-fidelity embryoids and organoids.Cell stem cell · 2022Review
- Cell position within human pluripotent stem cell colonies determines apical specialization via an actin cytoskeleton-based mechanism.Stem cell reports · 2022Article
- Agarose microgel culture delineates lumenogenesis in naive and primed human pluripotent stem cells.Stem cell reports · 2021Article
- Spatially resolved cell polarity proteomics of a human epiblast model.Science advances · 2021Article
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10 authors.
Funding
Abstract
Human pluripotent stem cells (hPSCs) self-organize into apicobasally polarized cysts, reminiscent of the lumenal epiblast stage, providing a model to explore key morphogenic processes in early human embryos. Here, we show that apical polarization begins on the interior of single hPSCs through the dynamic formation of a highly organized perinuclear apicosome structure. The membrane surrounding the apicosome is enriched in apical markers and displays microvilli and a primary cilium; its lumenal space is rich in Ca
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.