SynthesisJournal of orthopaedic surgery and research2017
An updated meta-analysis of the asporin gene D-repeat in knee osteoarthritis: effects of gender and ethnicity.
Synthesis in Journal of orthopaedic surgery and research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- A systematic comparative analysis of gait characteristics in patients undergoing total knee arthroplasty and unicompartmental knee arthroplasty: a review study.Journal of orthopaedic surgery and research · 2024Pooled it
- An Updated Systematic Review and Meta-analysis of Duloxetine for Knee Osteoarthritis Pain.The Clinical journal of pain · 2021Pooled it
- The association between rs12885713 polymorphism in CALM1 and risk of osteoarthritis: A meta-analysis of case-control studies.Medicine · 2018Pooled it
- The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Association between miRNA Target Sites and Incidence of Primary Osteoarthritis in Women from Volga-Ural Region of Russia: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2021Article
- Gait Analysis after Total Knee Arthroplasty Assisted by 3D-Printed Personalized Guide.BioMed research international · 2020Article
- Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundKnee osteoarthritis (KOA) is the most prevalent form of knee joint disease and characterized by the progressive degeneration of articular cartilage. Although pathology of KOA remains unknown, genetic factors are considered to be the major cause. Asporin is a group of biologically active components of extracellular matrix (ECM) in articular cartilage, and asporin gene (ASPN) D-repeat polymorphism was reported to be associated with KOA. Thus, our meta-analysis is aimed at investigation of the association between asporin D-repeat polymorphism and susceptibility of KOA.
methodsWe gathered data from MEDLINE, Embase, OVID, and ScienceDirect to search relevant published epidemiological studies through April 2017. Compared with previous studies, our meta-analysis is the first study to investigate the association of ASPN D15, D16, and D17 alleles and KOA susceptibility by ethnic- and sex-stratified subgroup analysis.
resultsWe found no significant association between D15 allele and susceptibility to KOA (OR = 1.05, 95% CI 0.95-1.17) in overall population. The same results were observed in the analysis of D16 (OR = 1.01, 95% CI 0.80-1.28) and D17 alleles (OR = 1.28, 95% CI 0.91-1.80). The ethnic- and sex-subgroup analyses did not alter the ORs. However, significant association was detected in the sensitivity analysis of D17 in overall population (OR = 1.05, 95% CI 0.95-1.17) and Asian population (OR = 1.78, 95% CI 1.02-3.11, P < 0.05).
conclusionOur results indicated that D-repeat polymorphism of ASPN may not play a major role in susceptibility of KOA in ethnic- and sex-specific analysis. Because of the limitations of the present meta-analysis, firm conclusions could not be drawn based on the current evidence, and further studies are required to detect genuine role of ASPN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.