Evidence map›Paper›PMID 29020853›Full record

SynthesisJournal of neurotrauma2021

Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting to Emergency Departments with Mild Brain Injury: A Living Systematic Review and Meta-Analysis.

Stefania Mondello, Abayomi Sorinola, Endre Czeiter, Zoltán Vámos, Krisztina Amrein, Anneliese Synnot, Emma Donoghue, János Sándor, Kevin K W Wang, Ramon Diaz-Arrastia and 4 more

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of neurotrauma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07782216 (Investigating the Significance of Protein Biomarkers During the Hyperacute Phase of Traumatic Brain Injury and Other CNS Conditions With Hypoxia/Hypoperfusion in Emergency and Prehospital Settings), which is not on this map. Cited by 85 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07782216 recruitingnot on this mapstarted 2026, after this paper: background citation

Investigating the Significance of Protein Biomarkers During the Hyperacute Phase of Traumatic Brain Injury and Other CNS Conditions With Hypoxia/Hypoperfusion in Emergency and Prehospital Settings (CHARON)

TypeobservationalSponsorUniversity of PecsRan2026 to 2028Enrolled477ConditionsBrain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Update on the role of S100B in traumatic brain injury in pediatric population: a meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Stefania MondelloDepartment of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
Abayomi SorinolaDepartment of Neurosurgery, University of Pecs, Pecs, Hungary.
Endre CzeiterDepartment of Neurosurgery, University of Pecs, Pecs, Hungary.
Zoltán VámosAnesthesiology and Intensive Therapy, University of Pecs, Pecs, Hungary.
Krisztina AmreinDepartment of Neurosurgery, University of Pecs, Pecs, Hungary.
Anneliese SynnotAustralian & New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Victoria, Australia.
Emma DonoghueAustralian & New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Victoria, Australia.
János SándorDepartment of Preventive Medicine, Division of Biostatistics and Epidemiology, University of Debrecen, Debrecen, Hungary.
Kevin K W WangProgram for Neuroproteomics & Biomarkers Research, Departments of Psychiatry & Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Ewout W SteyerbergCenter for Clinical Decision Sciences, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands.
David K MenonDivision of Anaesthesia, University of Cambridge, Cambridge, United Kingdom.
Andrew I R MaasDepartment of Neurosurgery, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium.
Andras BukiDepartment of Neurosurgery, University of Pecs, Pecs, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision making beyond current practice standards. We performed a systematic review and meta-analysis to comprehensively and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100 calcium binding protein B [S100B], glial fibrillary acidic protein [GFAP], neuron specific enolase [NSE], ubiquitin C-terminal hydrolase-L1 [UCH-L1]. tau, and neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI. Effects of potential confounding factors and differential diagnostic performance of the included markers were explored. Further, appropriateness of study design, analysis, quality, and demonstration of clinical utility were assessed. Studies published up to October 2016 were identified through searches of MEDLINE

Indexed as

Disease ManagementEmergency Service, HospitalAdultBiomarkersBlood ProteinsBrain ConcussionBrain Injuries, TraumaticGlial Fibrillary Acidic ProteinHumansNeurofilament ProteinsPhosphopyruvate HydrataseS100 Calcium Binding Protein beta SubunitBiomarkersBlood ProteinsGFAP protein, humanGlial Fibrillary Acidic ProteinNeurofilament ProteinsPhosphopyruvate HydrataseS100 Calcium Binding Protein beta Subunitbiomarkersdiagnosisliving systematic reviewmeta-analysisTBI

Identifiers

PMID29020853
PMCPMC8054517

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.