ArticleCancer research and treatment2018
Clinical Risk Factors Influencing Dental Developmental Disturbances in Childhood Cancer Survivors.
Article in Cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Best clinical practise guidance for oral health care management of long-term childhood cancer survivors (CCS): an EAPD policy document.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Guideline
- Clinical ascertainment of health outcomes in Asian survivors of childhood cancer: a systematic review.Journal of cancer survivorship : research and practice · 2019Pooled it
- A Case of Long-Term Management of Oral Function in a Child with Dyskeratosis Congenita.Diagnostics (Basel, Switzerland) · 2026Article
- Late Oral Complications in Childhood Cancer Survivors: Implications for Pediatric Dentistry and Survivorship Care.Children (Basel, Switzerland) · 2026Review
- A Case of Severe Early Childhood Caries Occurring in a Childhood Cancer Patient.Children (Basel, Switzerland) · 2025Article
- Dental dysplasia in childhood cancer survivors: a case series of permanent tooth abnormalities.Oral and maxillofacial surgery · 2024Article
- A Narrative Review of the Association between Dental Abnormalities and Chemotherapy.Journal of clinical medicine · 2024Review
- Parental awareness and dental health behavior of children with congenital heart disease, with diabetes mellitus, or undergoing anti-cancer treatment, compared to healthy children.Frontiers in oral health · 2024Article
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- Dental caries and dental developmental defects as adverse effects of antineoplastic treatment in childhood cancer survivors.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Article
- Oral and dental late effects in long-term survivors of childhood embryonal brain tumors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Oligomicrodontia in a Pediatric Cancer Survivor after Chemotherapy: A Case Report.Healthcare (Basel, Switzerland) · 2022Article
- Systemic Anticancer Therapy Details and Dental Adverse Effects in Children.International journal of environmental research and public health · 2022Article
- The prevalence of dental developmental anomalies among childhood cancer survivors according to types of anticancer treatment.Scientific reports · 2022Article
- An ex vivo organ culture screening model revealed that low temperature conditions prevent side effects of anticancer drugs.Scientific reports · 2022Article
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- Article
- The Broad Variability in Dental Age Observed among Childhood Survivors Is Cancer Specific.Cancer research and treatment · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAlthough studies regarding dental developmental disturbances after childhood cancer treatment have increased, they have many limitations. Studies analyzing the significance of independent clinical risk factors with regard to the dental health status are also rare. We aimed to investigate the risk factors for dental developmental disturbances, particularly severe disturbances, in childhood cancer survivors (CCS). MATERIALS AND
methodsOral examinations and retrospective reviews of medical and panoramic radiographs were performed for 196 CCS (mean age, 15.6 years). Cancer type, age at diagnosis, treatment modality, type and accumulated dose of administered drugs, and dose and site of radiation were recorded. Dental developmental disturbances were diagnosed using panoramic radiographs and graded for severity according to the Modified Dental Defect Index (MDDI). Descriptive statistics and multivariate analyseswere performed to determine the association between dental abnormalities and clinical factors.
resultsIn total, 109 CCS (55.6%) exhibited at least one dental anomaly, and the median value of MDDI was 2.5. Microdontia (30.6%) was the most prevalent anomaly, followed by tooth agenesis (20.4%), V-shaped roots (14.8%), and taurodontism (10.2%). Multivariate analysis revealed that a young age at diagnosis (≤ 3 years), a history of hematopoietic stem cell transplantation, the use of multiple classes of chemotherapeutic agents (≥ 4 classes), and the use of heavy metal agents were significant risk factors for severe dental disturbances.
conclusionCCS with any of the above risk factors for severe developmental disturbances should be comprehensively followed up to minimize adverse consequences to their dental development and preserve their future dental health.
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