Evidence map›Paper›PMID 29020631›Full record

ArticleCell reports2017

Covalent Modifications of Histone H3K9 Promote Binding of CHD3.

Adam H Tencer, Khan L Cox, Luo Di, Joseph B Bridgers, Jie Lyu, Xiaodong Wang, Jennifer K Sims, Tyler M Weaver, Hillary F Allen, Yi Zhang and 12 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Molecular Acrobats: How CHD Remodelers Shape the Genetic Playground to License Cell Identity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  5. Role of CHD chromatin remodelers in heart development.World journal of pediatrics : WJP · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Guiding the HBO1 complex function through the JADE subunit.Nature structural & molecular biology · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Epigenetic regulation ofAutophagy · 2024
    Review
  17. Non-histone binding functions of PHD fingers.Trends in biochemical sciences · 2023
    Review
  18. Article
  19. A Chemical Biology Primer for NMR Spectroscopists.Journal of magnetic resonance open · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 2 countries.

Adam H TencerDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Khan L CoxDepartment of Physics, Ohio State University, Columbus, OH 43210, USA.
Luo DiMolecular Modeling and Simulation Group, National Institutes for Quantum and Radiological Science and Technology, Kizugawa, Kyoto 619 0215, Japan.
Joseph B BridgersDepartment of Biochemistry and Biophysics and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Jie LyuDan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Xiaodong WangDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Jennifer K SimsLaboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Tyler M WeaverDepartment of Biochemistry, University of Iowa College of Medicine, Iowa City, IA 52242, USA.
Hillary F AllenDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Yi ZhangDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Jovylyn GatchalianDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Michael A DarcyDepartment of Physics, Ohio State University, Columbus, OH 43210, USA.
Matthew D GibsonDepartment of Physics, Ohio State University, Columbus, OH 43210, USA.
Jinzen IkebeMolecular Modeling and Simulation Group, National Institutes for Quantum and Radiological Science and Technology, Kizugawa, Kyoto 619 0215, Japan.
Wei LiDan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Paul A WadeLaboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
Jeffrey J HayesDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Brian D StrahlDepartment of Biochemistry and Biophysics and the Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
Hidetoshi KonoMolecular Modeling and Simulation Group, National Institutes for Quantum and Radiological Science and Technology, Kizugawa, Kyoto 619 0215, Japan.
Michael G PoirierDepartment of Physics, Ohio State University, Columbus, OH 43210, USA. Electronic address: poirier.18@osu.edu.
Catherine A MusselmanDepartment of Biochemistry, University of Iowa College of Medicine, Iowa City, IA 52242, USA. Electronic address: catherine-musselman@uiowa.edu.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: tatiana.kutateladze@ucdenver.edu.
University of Colorado Denver · USThe Ohio State University · USNational Institutes for Quantum and Radiological Science and Technology · JPBaylor College of Medicine · USNational Institute of Environmental Health Sciences · USUniversity of Iowa · USUniversity of North Carolina at Chapel Hill · USUniversity of Rochester Medical Center · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Eukaryotic Transcriptional RegulationZIAES101965 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WADE, PAUL A · 2009 to 2025
$40.9M
Salk Institute Cancer Training GrantT32CA009370 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Diana Clare Hargreaves, Jan Karlseder · 1986 to 2026
$8.6M
Histone Tall Interactions and Functions in ChromatinR01GM052426 · NIGMS · UNIVERSITY OF ROCHESTER · PI HAYES, JEFFREY J · 1995 to 2021
$6.2M
BEHAVIORAL PHARMACOGENETICS OF DRUG AND ALCOHOL ABUSET32AA007464 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI HOFFMAN, PAULA · 1987 to 2017
$4.8M
Role of Set2 and H3 methylation in chromatin functionR01GM068088 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STRAHL, BRIAN D · 2003 to 2017
$3.4M
Mechanisms of Chromatin Transcriptional RegulationR01GM083055 · NIGMS · OHIO STATE UNIVERSITY · PI POIRIER, MICHAEL GUY · 2008 to 2016
$2.7M
Epigenetic regulation by PHF1R01GM106416 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.5M
Molecular mechanism of chromatin targeting by BRPF1R01GM100907 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2015 to 2018
$1.4M
Interdomain crosstalk in MORC3R01GM125195 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2017 to 2021
$1.3M
Regulatory Mechanisms of Linker Histones and Their Post-Translational ModificationsR01GM121966 · NIGMS · OHIO STATE UNIVERSITY · PI POIRIER, MICHAEL GUY · 2017 to 2020
$1.2M
NCI NIH HHS T32 CA009370NIAAA NIH HHS T32 AA007464NIGMS NIH HHS R01 GM052426NIGMS NIH HHS R01 GM068088NIGMS NIH HHS R01 GM083055NIGMS NIH HHS R01 GM100907NIGMS NIH HHS R01 GM106416NIGMS NIH HHS R01 GM121966NIGMS NIH HHS R01 GM125195
6 · The paper itself

Abstract

Chromatin remodeling is required for genome function and is facilitated by ATP-dependent complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core components is the chromodomain helicase DNA binding protein 3 (CHD3) whose functional significance is not well established. Here, we show that CHD3 co-localizes with the other NuRD subunits, including HDAC1, near the H3K9ac-enriched promoters of the NuRD target genes. The tandem PHD fingers of CHD3 bind histone H3 tails and posttranslational modifications that increase hydrophobicity of H3K9-methylation or acetylation (H3K9me3 or H3K9ac)-enhance this interaction. Binding of CHD3 PHDs promotes H3K9

Indexed as

Histone CodeAcetylationAnimalsBinding SitesDNA HelicasesHEK293 CellsHistone Deacetylase 1HistonesHumansMethylationMi-2 Nucleosome Remodeling and Deacetylase ComplexMolecular Docking SimulationPromoter Regions, GeneticProtein BindingProtein Processing, Post-TranslationalXenopusCHD3 protein, humanDNA HelicasesHDAC1 protein, humanHistone Deacetylase 1HistonesMi-2 Nucleosome Remodeling and Deacetylase ComplexCHD3chromatinH3K9acH3K9me3histoneNuRDPHD finger

Identifiers

PMID29020631
PMCPMC5653232
OpenAlexW2762543439

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.