ArticleThe international journal of neuropsychopharmacology2017
Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in The international journal of neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 30% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Cerebral serotonin transporter measurements with [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Pooled it
- Different preprocessing strategies lead to different conclusions: A [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Network-based mapping and neurotransmitter architecture of gray matter correlates of neuroticism.Frontiers in systems neuroscience · 2025Article
- No association between serotonin 4 receptor brain binding and personality trait Neuroticism - A positron emission tomography study in depressed patients and healthy individuals.Neuroscience applied · 2024Article
- The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits.Frontiers in psychiatry · 2023Article
- Brain serotonin transporter is associated with cognitive-affective biases in healthy individuals.Human brain mapping · 2022Article
- The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.Journal of cellular and molecular medicine · 2021Article
- Associations Among Monoamine Neurotransmitter Pathways, Personality Traits, and Major Depressive Disorder.Frontiers in psychiatry · 2020Review
- Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women.Brain and behavior · 2019Article
- Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study.Human brain mapping · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Lauri TuominenTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Jouko MiettunenTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Dara M CannonTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Wayne C DrevetsTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Vibe G FrokjaerTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Jussi HirvonenTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Masanori IchiseTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Peter S JensenTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Liisa Keltikangas-JärvinenTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Jacqueline M KlaverTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Gitte M KnudsenTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Akihiro TakanoTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Tetsuya SuharaTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Jarmo HietalaTurku PET Centre, Turku University Hospital, Turku, Finland; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Cambridge, MA; Center for Life Course Health Research, University of Oulu, Finland & Medical Research Center (MRC) Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland, Galway, Ireland; Janssen Research & Development, LLC, of Johnson & Johnson, Titusville, NJ; Neurobiology Research Unit, Rigshospitalet, Denmark; Center for Integrated Molecular Brain Imaging, Rigshospitalet, Denmark; Department of Radiology, University of Turku, Turku, Finland; Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan; IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, Helsinki, Finland; Department of Psychology, Southern Illinois University, Carbondale, Illinois; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Center for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, University of Turku, Turku, Finland.
Oulu University Hospital · FI
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotonergic system and the risk that neuroticism poses to the individual, sex may modify the association between neuroticism and serotonin transporter, but this question has not been investigated by previous studies. Methods: Here, we combined data from 4 different positron emission tomography imaging centers to address whether neuroticism is related to serotonin transporter binding in vivo. The data set included serotonin transporter binding potential values from the thalamus and striatum and personality scores from 91 healthy males and 56 healthy females. We specifically tested if the association between neuroticism and serotonin transporter is different in females and males. Results: We found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality. Higher neuroticism associated with higher serotonin transporter binding potential in males (standardized beta 0.292, P=.008), whereas in females, higher neuroticism associated with lower serotonin transporter binding potential (standardized beta -0.288, P=.014). Conclusions: The finding is in agreement with recent studies showing that the serotonergic system is involved in affective disorders differently in males and females and suggests that contribution of thalamic serotonin transporter to the risk of affective disorders depends on sex.
Indexed as
NeuroticismSex CharacteristicsAdolescentAdultCerebral CortexFemaleHumansInternational CooperationMaleMiddle AgedPositron-Emission TomographyProtein BindingRegression AnalysisSerotonin Plasma Membrane Transport ProteinsYoung AdultSerotonin Plasma Membrane Transport ProteinsneuroticismPETserotoninserotonin transportersex
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.