Evidence map›Paper›PMID 29020381›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018

Antibody Banding Patterns of the Enzyme-Linked Immunoelectrotransfer Blot and Brain Imaging Findings in Patients With Neurocysticercosis.

Gianfranco Arroyo, Silvia Rodriguez, Andres G Lescano, Karen A Alroy, Javier A Bustos, Saul Santivañez, Isidro Gonzales, Herbert Saavedra, E Javier Pretell, Armando E Gonzalez and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Older Age in Subarachnoid Neurocysticercosis Reflects a Long Prepatent Period.The American journal of tropical medicine and hygiene · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Mortality in Parenchymal and Subarachnoid Neurocysticercosis.The American journal of tropical medicine and hygiene · 2021
    Article
  16. Review
  17. Current Diagnostic Criteria for Neurocysticercosis.Research and reports in tropical medicine · 2021
    Review
  18. Article
  19. Unique Characteristics of Epilepsy Development in Neurocysticercosis.The American journal of tropical medicine and hygiene · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Gianfranco ArroyoSchool of Public Health and Management, Universidad Peruana Cayetano Heredia, Lima, Peru.
Silvia RodriguezCysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Andres G LescanoSchool of Public Health and Management, Universidad Peruana Cayetano Heredia, Lima, Peru.
Karen A AlroyDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Javier A BustosSchool of Public Health and Management, Universidad Peruana Cayetano Heredia, Lima, Peru.
Saul SantivañezInstituto Peruano de Parasitología Clínica y Experimental, Lima.
Isidro GonzalesCysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
Herbert SaavedraCysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.
E Javier PretellDepartment of Neurology, Hospital Alberto Sabogal, Callao.
Armando E GonzalezSchool of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru.
Robert H GilmanDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Victor C W TsangGeorgia State University, Atlanta.
Hector H GarciaSchool of Public Health and Management, Universidad Peruana Cayetano Heredia, Lima, Peru.
Cysticercosis Working Group in Peru
Universidad Peruana Cayetano Heredia · PEInstituto Nacional de Enfermedades Neoplásicas · PEJohns Hopkins University · USGeorgia State University · USNational University of San Marcos · PEInstitute of Peruvian Studies · PEUniversidad Nacional del Callao · PE

Funding

Peru Infectious Diseases Epidemiology Research Training ConsortiumD43TW007393 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI Andres G Lescano · 2005 to 2026
$5.9M
Training in Parasitic Diseases and Central Nervous System Infections in Peru.D43TW001140 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI GARCIA, HECTOR HUGO, GILMAN, ROBERT H · 1999 to 2025
$5.7M
Scientific CoreU19AI129909 · NIAID · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI GONZALEZ, ARMANDO EMILIANO · 2017 to 2021
$2.8M
FIC NIH HHS D43 TW001140FIC NIH HHS D43 TW007393Medical Research Council MR/K007467/1NIAID NIH HHS U19 AI129909
6 · The paper itself

Abstract

Background: The enzyme-linked immunoelectrotransfer blot (EITB) assay is the reference serological test for neurocysticercosis (NCC). A positive result on EITB does not always correlate with the presence of active infections in the central nervous system (CNS), and patients with a single viable brain cyst may be EITB negative. Nonetheless, EITB antibody banding patterns appears to be related with the expression of 3 protein families of Taenia solium, and in turn with the characteristics of NCC in the CNS (type, stage, and burden of viable cysts). Methods: We evaluated EITB antibody banding patterns and brain imaging findings of 548 NCC cases. Similar banding patterns were grouped into homogeneous classes using latent class analysis. The association between classes and brain imaging findings was assessed. Results: Four classes were identified. Class 1 (patients negative or only positive to the GP50 band, related to the protein family of the same name) was associated with nonviable or single viable parenchymal cysticerci; class 2 (patients positive to bands GP42-39 and GP24, related to the T24-42 protein family, with or without anti-GP50 antibodies) was associated with intraparenchymal viable and nonviable infections; classes 3 and 4 (positive to GP50, GP42-39, and GP24 but also responding to low molecular weight bands GP21, GP18, GP14, and GP13, related to the 8 kDa protein family) were associated with extraparenchymal and intraparenchymal multiple viable cysticerci. Conclusions: EITB antibody banding patterns correlate with brain imaging findings and complement imaging information for the diagnosis of NCC and for staging NCC patients.

Indexed as

AdultAgedAnimalsAntibodies, HelminthBrainCross-Sectional StudiesFemaleHumansImmunoblottingMaleMiddle AgedNeurocysticercosisNeuroimagingTaenia soliumAntibodies, HelminthEITBepilepsyneurocysticercosisPeruTaenia solium

Identifiers

PMID29020381
PMCPMC5850523
OpenAlexW2792629427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.