ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2018
The Transmissibility of Antibiotic-Resistant Enterobacteriaceae in Intensive Care Units.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Is systematic fecal carriage screening of extended-spectrum beta-lactamase-producing Enterobacteriaceae still useful in intensive care unit: a systematic review.Critical care (London, England) · 2019Pooled it
- HypervirulentPharmaceuticals (Basel, Switzerland) · 2025Review
- Prioritizing isolation precautions: a patient-centered approach to infection prevention and control.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Review
- The Rapid Emergence of HypervirulentTropical medicine and infectious disease · 2024Review
- Transmission of drug-resistant bacteria in a hospital-community model stratified by patient risk.Scientific reports · 2023Article
- Impact of Antibiotic Consumption on the Acquisition of Extended-Spectrum β-Lactamase ProducingAntibiotics (Basel, Switzerland) · 2022Article
- Genetic Characterization of Multidrug-ResistantMicroorganisms · 2022Article
- Impact of the COVID-19 pandemic on the surveillance of antimicrobial resistance.The Journal of hospital infection · 2021Article
- Article
- Genomic surveillance of antimicrobial resistant bacterial colonisation and infection in intensive care patients.BMC infectious diseases · 2021Article
- Short-term increase in the carriage of azithromycin-resistantJAC-antimicrobial resistance · 2021Article
- Relevance of intra-hospital patient movements for the spread of healthcare-associated infections within hospitals - a mathematical modeling study.PLoS computational biology · 2021Article
- Cost-effectiveness analysis of whole-genome sequencing during an outbreak of carbapenem-resistantAntimicrobial stewardship & healthcare epidemiology : ASHE · 2021Article
- Antibiotic Resistance: One Health One World Outlook.Frontiers in cellular and infection microbiology · 2021Review
- Modelling pathogen spread in a healthcare network: Indirect patient movements.PLoS computational biology · 2020Article
- Less contact isolation is more in the ICU: not sure.Intensive care medicine · 2020Article
- Less contact isolation is more in the ICU: con.Intensive care medicine · 2020Article
- Prevalence and Risk Factors for Extended-Spectrum β-Lactamase-ProducingAnnals of laboratory medicine · 2020Article
- A hybrid simulation model approach to examine bacterial genome sequencing during a hospital outbreak.BMC infectious diseases · 2020Article
- A One Health Study of the Genetic Relatedness of Klebsiella pneumoniae and Their Mobile Elements in the East of England.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
Corrections and comments
- Commented on by
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The global emergence of infections caused by Enterobacteriaceae resistant to expanded-spectrum cephalosporins (ESCs) in intensive care units (ICUs) is, at least partly, driven by cross-transmission. Yet, individual transmission capacities of bacterial species have not been quantified. Methods: In this post hoc analysis of a multicenter study in 13 European ICUs, prospective surveillance data and a mathematical model were used to estimate transmission capacities and single-admission reproduction numbers (RA) of Escherichia coli and non-E. coli Enterobacteriaceae (non-EcE), all being ESC resistant. Surveillance was based on a chromogenic selective medium for ESC-resistant Enterobacteriaceae, allowing identification of E. coli and of Klebsiella, Enterobacter, Serratia, and Citrobacter species, grouped as non-EcE. Results: Among 11420 patients included, the admission prevalence was 3.8% for non-EcE (74% being Klebsiella pneumoniae) and 3.3% for E. coli. Acquisition rates were 7.4 and 2.6 per 100 admissions at risk for non-EcE and E. coli, respectively. The estimated transmission capacity of non-EcE was 3.7 (95% credibility interval [CrI], 1.4-11.3) times higher than that of E. coli, yielding single-admission reproduction numbers (RA) of 0.17 (95% CrI, .094-.29) for non-EcE and 0.047 (95% CrI, .018-.098) for E. coli. Conclusions: In ICUs, non-EcE, mainly K. pneumoniae, are 3.7 times more transmissible than E. coli. Estimated RA values of these bacteria were below the critical threshold of 1, suggesting that in these ICUs outbreaks typically remain small with current infection control policies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.