Trial reportEuropean heart journal2017
Staging classification of aortic stenosis based on the extent of cardiac damage.
Trial report in European heart journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05024942 (Lung Ultrasound in Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement), which is not on this map. Cited by 296 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lung Ultrasound in Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement: a Prospective Study
Who cites it
296 citing papers in PubMed, 4 syntheses or guidelines pooled it, 674 citations in OpenAlex.
- Right ventricular function assessment following transcatheter aortic valve implantation/replacement (TAVI/TAVR): a systematic review and meta-analysis comparing speckle tracking and conventional echocardiographic approaches.Journal of echocardiography · 2026Pooled it
- Mortality after urgent versus elective transcatheter aortic valve replacement: a systematic review and meta-analysis using reconstructed individual patient data from Kaplan-Meier curves.BMC cardiovascular disorders · 2025Pooled it
- A meta-analysis of left ventricular dysfunction in ankylosing spondylitis.Journal of clinical hypertension (Greenwich, Conn.) · 2024Pooled it
- Moderate Aortic Valve Stenosis Is Associated With Increased Mortality Rate and Lifetime Loss: Systematic Review and Meta-Analysis of Reconstructed Time-to-Event Data of 409 680 Patients.Journal of the American Heart Association · 2024Pooled it
- Age and Procedural Timing for Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial.Circulation. Cardiovascular interventions · 2026Trial
- Echocardiographic Results of Transcatheter Versus Surgical Aortic Valve Replacement in Women With Severe Aortic Stenosis: The RHEIA Trial.Journal of the American Heart Association · 2026Trial
- Article
- Life-expectancy paradox and the selection of older patients with aortic stenosis for valve intervention.Open heart · 2026Review
- Cardiac damage stages at follow-up and subsequent clinical outcomes in patients with severe aortic stenosis.Cardiovascular intervention and therapeutics · 2026Article
- Trajectories of cardiac damage staging after transcatheter aortic valve replacement and long-term outcomes.Cardiovascular intervention and therapeutics · 2026Article
- Predicting left-ventricular recovery and characterizing Cardiorenal risk after Transcatheter aortic valve replacement: A routine-data phenotyping and prediction-model study.International journal of cardiology. Heart & vasculature · 2026Article
- Observational
- Integration of multiple perspectives to understand the left ventricular pressure-volume relationship.Communications medicine · 2026Review
- Association Between the Degree of Extravalvular Cardiac Damage and the Severity of Aortic Stenosis.JACC. Advances · 2026Article
- Moderate aortic stenosis: diagnostic pitfalls and the role of multimodality imaging in risk stratification and clinical management.Cardiovascular ultrasound · 2026Review
- Prognostic Impact of Main Pulmonary Artery Enlargement in Patients Undergoing Transcatheter Aortic Valve Replacement.CJC open · 2026Article
- Article
- Balloon Aortic Valvuloplasty as a Bridge Therapy in Acute Valve Syndrome: A Narrative Review of Evidence Gaps and Future Directions.Structural heart : the journal of the Heart Team · 2026Review
- Shifting From Anatomical to Functional Abnormalities.JACC. Asia · 2026Article
- Staged Therapeutic Approach to Concomitant Severe Aortic Stenosis and Atrial Septal Defect: Addressing Dual Mechanisms of Heart Failure-Case Report and Literature Review.Life (Basel, Switzerland) · 2026Article
236 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
24 authors at 14 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsIn patients with aortic stenosis (AS), risk stratification for aortic valve replacement (AVR) relies mainly on valve-related factors, symptoms and co-morbidities. We sought to evaluate the prognostic impact of a newly-defined staging classification characterizing the extent of extravalvular (extra-aortic valve) cardiac damage among patients with severe AS undergoing AVR. METHODS AND
resultsPatients with severe AS from the PARTNER 2 trials were pooled and classified according to the presence or absence of cardiac damage as detected by echocardiography prior to AVR: no extravalvular cardiac damage (Stage 0), left ventricular damage (Stage 1), left atrial or mitral valve damage (Stage 2), pulmonary vasculature or tricuspid valve damage (Stage 3), or right ventricular damage (Stage 4). One-year outcomes were compared using Kaplan-Meier techniques and multivariable Cox proportional hazards models were used to identify 1-year predictors of mortality. In 1661 patients with sufficient echocardiographic data to allow staging, 47 (2.8%) patients were classified as Stage 0, 212 (12.8%) as Stage 1, 844 (50.8%) as Stage 2, 413 (24.9%) as Stage 3, and 145 (8.7%) as Stage 4. One-year mortality was 4.4% in Stage 0, 9.2% in Stage 1, 14.4% in Stage 2, 21.3% in Stage 3, and 24.5% in Stage 4 (Ptrend < 0.0001). The extent of cardiac damage was independently associated with increased mortality after AVR (HR 1.46 per each increment in stage, 95% confidence interval 1.27-1.67, P < 0.0001).
conclusionThis newly described staging classification objectively characterizes the extent of cardiac damage associated with AS and has important prognostic implications for clinical outcomes after AVR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.