ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2017
Systemic Inflammatory Response to Malaria During Pregnancy Is Associated With Pregnancy Loss and Preterm Delivery.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01168271 (Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Preconception health risks among women of reproductive age in Sub-Saharan Africa: a systematic review of implications for preconception care.Journal of health, population, and nutrition · 2025Pooled it
- Trial
- Systemic inflammation is associated with malaria and preterm birth in women living with HIV on antiretrovirals and co-trimoxazole.Scientific reports · 2019Trial
- Clinical, parasitological, and hematologic profile of pregnant women with malaria in Colombia: a retrospective cross-sectional study.IJID regions · 2026Article
- Compartment-specific soluble immune profiles associated with preterm birth, perinatal death, and low birthweight in pregnant individuals living with HIV.bioRxiv : the preprint server for biology · 2026Article
- MaternalbioRxiv : the preprint server for biology · 2026Article
- cTfh Cell Activation and Changes in BTLA and LAG-3 Expression Differentially Associate With Poor Pregnancy Outcome in Plasmodium falciparum Placental Malaria.Journal of immunology research · 2026Article
- Multi-system dysregulation in placental malaria contributes to adverse perinatal outcomes in mice.Infection and immunity · 2025Article
- Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria.PLoS pathogens · 2025Article
- Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women.PLoS neglected tropical diseases · 2024Observational
- Alteration of Trophoblast Syncytialization byMicroorganisms · 2024Article
- Review
- Decidual leukocytes respond to African lineage Zika virus infection with mild anti-inflammatory changes during acute infection in rhesus macaques.Frontiers in immunology · 2024Article
- Aberrant CD8Frontiers in immunology · 2024Article
- Review
- Spontaneous abortion is associated with differentially expressed angiogenic chemokines in placenta and decidua.Archives of gynecology and obstetrics · 2023Article
- Sequential disruptions to inflammatory and angiogenic pathways and risk of spontaneous preterm birth in Malawian women.iScience · 2023Article
- Article
- Article
- Stillbirth incidence and determinants in a tertiary health facility in the Volta Region of Ghana.PloS one · 2023Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPregnancy malaria (PM) is associated with a proinflammatory immune response characterized by increased levels of cytokines and chemokines such as tumor necrosis factor-α, interferon-γ, interleukin 10 (IL-10), and CXCL9. These changes are associated with poor outcomes including low birthweight delivery and maternal anemia. However, it is unknown if inflammatory pathways during malaria are related to pregnancy loss and preterm delivery (PTD).
methodsCytokine and chemokine levels were measured in maternal peripheral blood at enrollment, gestational week 30-32, and delivery, and in placental blood, of 638 women during a longitudinal cohort study in Ouelessebougou, Mali. Plasmodium falciparum infection was assessed by blood smear microscopy at all visits.
resultsPM was associated with increased levels of cytokines and chemokines including IL-10 and CXCL9. In a competing risks model adjusted for known covariates, high CXCL9 levels measured in the peripheral blood during pregnancy were associated with increased risk of pregnancy loss and PTD. At delivery, high IL-10 levels in maternal blood were associated with an increase in pregnancy loss, and increased IL-1β levels in placental blood were associated with pregnancy loss and PTD.
conclusionsPM is associated with increased proinflammatory cytokine and chemokine levels in placental and maternal peripheral blood. Systemic inflammatory responses to malaria during pregnancy predict increased risk of pregnancy loss and PTD. CLINICAL TRIALS REGISTRATION: NCT01168271.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.