ArticleAmerican journal of epidemiology2018
Breast Cancer Incidence and Exposure to Metalworking Fluid in a Cohort of Female Autoworkers.
Article in American journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prostate cancer incidence and mortality linked to metalworking fluid exposure: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Environmental exposures and breast cancer risk in the context of underlying susceptibility: A systematic review of the epidemiological literature.Environmental research · 2020Pooled it
- Exposure to Metalworking Fluids and Cancer Incidence in the United Auto Workers-General Motors Cohort.American journal of epidemiology · 2023Article
- Breast Cancer Incidence among Female Workers by Different Occupations and Industries: A Longitudinal Population-Based Matched Case-Control Study in Taiwan.International journal of environmental research and public health · 2022Article
- Breast cancer and occupational exposures: an integrative review of the literature.Revista brasileira de medicina do trabalho : publicacao oficial da Associacao Nacional de Medicina do Trabalho-ANAMT · 2021Review
- Metalworking fluids and cancer mortality in a US autoworker cohort (1941-2015).Scandinavian journal of work, environment & health · 2020Article
- Maternal Occupational Oil Mist Exposure and Birth Defects, National Birth Defects Prevention Study, 1997⁻2011.International journal of environmental research and public health · 2019Article
- Metalworking Fluids and Colon Cancer Risk: Longitudinal Targeted Minimum Loss-based Estimation.Environmental epidemiology (Philadelphia, Pa.) · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Breast cancer is the leading cancer diagnosed among women, and environmental studies have produced few leads on modifiable risk factors for breast cancer. Following an Institute of Medicine recommendation for occupational studies of women highly exposed to potential breast cancer risk factors, we took advantage of an existing cohort of 4,503 female autoworkers in Michigan exposed to metalworking fluid (MWF), complex mixtures of oils and chemicals widely used in metal manufacturing worldwide. Cox proportional hazards models were fit to estimate hazard ratios for incident breast cancer (follow-up, 1985-2013) and cumulative exposure (20-year lag) to straight mineral oils (a known human carcinogen) and water-based soluble and synthetic MWF. Because the state cancer registry began decades after the cohort was defined, we restricted our analyses to subcohorts of women hired closer to the start of follow-up. Among those hired after 1969, the hazard ratio associated with a 1 interquartile-range increase in straight MWF exposure was 1.13 (95% confidence interval: 1.03, 1.23). In separate analyses of premenopausal breast cancer, defined by age at diagnosis, the hazard ratio was elevated for exposure to synthetic MWF (chemical lubricants with no oil content), possibly suggesting a different mechanism in the younger women with breast cancer. This study adds to the limited literature regarding quantitative chemical exposures and breast cancer risk.
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